Energy solvency. A new concept to prevent energy poverty in Spain.

The new concept of energy solvency is defined as the ability of a person buying or renting a dwelling to meet the energy costs necessary to keep the dwelling comfortable, without falling into energy poverty. The energy efficiency certificate information is used to calculate the economic expenditure that is theoretically necessary to maintain the property comfortable. This is a more robust value for calculating the energy poverty indicator 2 M than the available data on real expenditure.

The MEGA Project: A Study of the Mechanisms Involved in the Genesis and Disease Course of Asthma. Asthma Cohort Creation and Long-Term Follow-Up.

The general aim of this study is to create a cohort of asthma patients with varying grades of severity in order to gain greater insight into the mechanisms underlying the genesis and course of this disease. The specific objectives focus on various studies, including imaging, lung function, inflammation, and bronchial hyperresponsiveness, to determine the relevant events that characterize the asthma population, the long-term parameters that can determine changes in the severity of patients, and the treatments that influence disease progression. The study will also seek to identify the causes of exacerbations and how this affects the course of the disease.

Con: The use of calcineurin inhibitors in the treatment of lupus nephritis.

Lupus nephritis (LN) therapy has limited efficacy due to its toxicity, and LN patients suffer high risks of renal and cardiovascular morbidity and mortality. Calcineurin inhibitors (CNIs) have been used for over >30 years in LN treatment and are an established alternative therapy for Class V nephritis, but uncertainty remains about their role in proliferative disease or in the maintenance of remission. More recently, the combination of CNIs with mycophenolate mofetil (MMF) and glucocorticoid combination therapy, 'multitarget' therapy and the use of tacrolimus as opposed to ciclosporin has received attention.