Publications by authors named "Maria Fernanda Sanchez Vallecillo"
Polymeric antigen BLSOmp31 formulated with class B CpG-ODN in a nanostructure (BLSOmp31/CpG-ODN/Coa-ASC16) administered by parenteral or mucosal routes confers protection against Brucella ovis in Balb/c mice.
María Celeste Moran Angel Ricardo Bence María Fernanda Sánchez Vallecillo Claudia María Lützelschwab Marcelo Gastón Rodriguez
Res Vet Sci
March 2021
Previously, we demonstrated that the chimera BLSOmp31 formulated in chitosan microspheres or Poloxamer407-Chitosan administered via the nasal and the ocular mucosa conferred partial protection in sheep against B. ovis. In this work, we tested a new delivery system for mucosal immunization with BLSOmp31 in the murine model to improve the efficacy of previously used formulations.
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- Fasciolosis, caused by a helminth parasite, primarily affects livestock and sometimes humans, with Triclabendazole being the main treatment; however, resistance to this drug has emerged.
- Research focused on a novel vaccine using a Kunitz-type molecule (FhKTM) combined with a liquid crystal nanostructure and synthetic oligodeoxynucleotide to enhance immune response in mice against fasciolosis.
- Findings indicated that this vaccine formulation offered significant protection, improved survival rates, and promoted robust immune responses, suggesting its potential use for controlling infections in cattle and sheep.