Publications by authors named "Maria Fabiana De Rosa"
Article Synopsis
- * It highlights a study that examines drug efflux transporters in rectal tissues from both HIV-infected and uninfected men, focusing on their potential role in the effectiveness of PrEP medications.
- * The findings reveal that HIV-infected individuals on ART show higher levels of certain drug transporters compared to those not on ART, suggesting that HIV and ART can influence drug transport in the gut, which may impact how well PrEP works.
Multidrug resistance (MDR) via the ABC drug transporter (ABCB1), P-glycoprotein (P-gp/MDR1) overexpression, is a major obstacle in cancer chemotherapy. Many inhibitors reverse MDR but, like cyclosporin A (CsA), have significant toxicities. MDR1 is also a translocase that flips glucosylceramide inside the Golgi to enhance neutral glycosphingolipid (GSL) synthesis.
View Article and Find Full Text PDFTransfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi complex (Lala, P., Ito, S., and Lingwood, C.
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