Publications by authors named "Maria F Serafim"
Pain management after total joint arthroplasty is often addressed by systemic delivery of opioids. Local delivery of non-opioid analgesic drugs directly in the joint space from the UHMWPE component of the prosthesis would be highly beneficial to increase the efficacy of the drugs, decreasing the overall side effects and the risk of opioid addiction. It has been shown that effective concentrations of local analgesics can be achieved by eluting from analgesic-blended UHMWPE; however, this approach is limited by the decrease in mechanical properties resulting from the extent of phase separation of the blended drugs from the polymeric matrix.
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- * The composition of MSC-EVs varies based on the tissue source of the MSCs and the methods used for their culture and isolation, highlighting the need for careful selection of MSC sources and culture techniques.
- * The review analyzes molecular characteristics of MSC-EVs from different tissues using public datasets and AI techniques, revealing distinct biological pathways linked to various sources like adipose, bone marrow, and umbilical MSCs, which is crucial for advancing their therapeutic applications.
Extracellular vesicles (EVs) have various advantageous properties, including a small size, high biocompatibility, efficient cargo loading, and precise cell targeting ability, making them promising tools for therapeutic development. EVs have been increasingly explored for applications like drug delivery. However, due to limited cellular secretion rates of EVs, wide-scale clinical applications are not achievable.
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