Melanins from two selected isolates of Pseudocercospora griseola grown in-vitro: Chemical features and redox activity.

Pseudocercospora griseola is the causal agent of Angular Leaf Spot (ALS), a disease of common bean. Due to its coevolution with beans, two major groups have been defined, "Andean" (P. griseola f.

[Quality assessment of clinical practice guidelines of the Chilean explicit guarantees in healthcare program].

Background: High quality practice guidelines are of utmost importance in clinical medicine.

Aim: To evaluate the methodological quality of Clinical Practice Guidelines (CPG) for 80 high burden health conditions included in the “Explicit Guarantees in Healthcare” (EGH) program available on July 2014, elaborated and published by the Ministry of Health of Chile.

Material And Methods: A cross-sectional observational study using the Appraisal of Guidelines Research and Evaluation (AGREE II) instrument to evaluate the methodological quality of the current CPGs for EGH.

A comparative QSAR on 1,2,5-thiadiazolidin-3-one 1,1-dioxide compounds as selective inhibitors of human serine proteinases.

Selective inhibitors of target serine proteinases have a potential therapeutic role for the treatment of various inflammatory and related diseases. We develop a comparative quantitative structure-activity relationships based analysis on compounds embodying the 1,2,5-thiadiazolidin-3-one 1,1-dioxide scaffold. By means of classical Molecular Dynamics we obtain the conformation of each lowest-energy molecular structure from which we derive more than a thousand of structural descriptors necessary for building predictive QSAR models.

Dexamethasone inhibits BAFF expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Fibroblast-like synoviocytes (FLS) play a major role in the pathogenesis of rheumatoid arthritis (RA). FLS isolated from patients with RA (FLS-RA) express B cell-activating factor belonging to the TNF family (BAFF), a cytokine that has been associated with the onset and progression of RA. Glucocorticoids are powerful anti-inflammatory drugs used in the treatment of RA.