Molecular annotation of G protein variants in a neurological disorder.

Heterotrimeric G proteins transduce extracellular chemical messages to generate appropriate intracellular responses. Point mutations in GNAO1, encoding the G protein α subunit, have been implicated in a pathogenic condition characterized by seizures, movement disorders, intellectual disability, and developmental delay (GNAO1 disorder). However, the effects of these mutations on G protein structure and function are unclear.

Multisystem inflammatory syndrome in children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain.

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe disease temporarily related to SARS-CoV-2. We aimed to describe the epidemiological, clinical, and laboratory findings of all MIS-C cases diagnosed in children < 18 years old in Catalonia (Spain) to study their trend throughout the pandemic. This was a multicenter ambispective observational cohort study (April 2020-April 2022).

Groundwater Flow Processes and Human Impact along the Arid US-Mexican Border, Evidenced by Environmental Tracers: The Case of Tecate, Baja California.

With the increasing population, urbanization and industry in the arid area of Tecate, there is a concomitant increase in contaminants being introduced into the Tecate River and its aquifer. This contamination is damaging the usable groundwater supply and making local residents and commercial enterprises increasingly dependent on imported water from the Colorado River basin. In this study we apply a suite of chemical and isotopic tracers in order to evaluate groundwater flow and assess contamination trends.

Territorial approach to increased energy consumption of water extraction from depletion of a highlands Mexican aquifer.

This work proposes a method to estimate increased energy consumption of pumping caused by a drawdown of groundwater level and the equivalent energy consumption of the motor-pump system in an aquifer under intensive exploitation. This method has been applied to the Valley of Toluca aquifer, located in the Mexican highlands, whose intensive exploitation is reflected in a decline in the groundwater level of between 0.10 and 1.

Environmental effects of aquifer overexploitation: a case study in the highlands of Mexico.

There are several environmental processes occurring under aquifer overexploitation conditions. These processes include groundwater table decline, subsidence, attenuation and drying of springs, decrease of river flow, and increased pollution vulnerability, among others processes. Some of these effects have been observed on the Upper Basin of the Lerma River.