Publications by authors named "Maria Encarnacion Morales"
Int J Mol Sci
December 2021
Article Synopsis
- Exogenous neuroprotective protein neuroglobin (Ngb) is unable to cross the blood-brain barrier, so researchers developed hyaluronate nanoparticles (NPs) to deliver Ngb into the brain for stroke treatment.
- In an animal model of stroke, Ngb-NPs significantly increased survival rates by up to 50% and improved neurological outcomes compared to untreated animals, despite no change in infarct volume or oxidative values.
- Proteomics analysis found 219 proteins with altered expression post-treatment, revealing Ngb's influence on crucial processes related to cell death, mitochondrial function, and regeneration, suggesting potential for advancing stroke and neurodegenerative disorder treatments.
Pharmaceutics
January 2020
Article Synopsis
- Current stroke therapies can restore blood flow but fail to prevent brain damage or aid recovery in affected areas.
- The neuroglobin protein, important for brain regeneration post-stroke, struggles to cross the blood-brain barrier, complicating its effective use.
- Researchers developed sodium hyaluronate nanoparticles to deliver neuroglobin to nerve cells in stroke-affected rats, showing promising results in transportation and potential neuroprotective effects.
Eur J Pharm Sci
January 2018
Article Synopsis
- * This research focused on creating a new vaginal tablet featuring Lactobacillus spp. bacteria, ultimately selecting the optimal formulation F4 based on its effective swelling, dissolution, and mucoadhesion properties.
- * The F4 tablets demonstrated quick disintegration in simulated vaginal fluid and provided two distinct release profiles for the bacteria: an immediate release and a sustained release lasting up to 24 hours, while maintaining viable bacteria for 90 days during storage.
