Publications by authors named "Maria Elisa Chuery Martins Rostelato"

. To estimate dose rates delivered by using radioactiveAu nanoparticles for prostate cancer nanobrachytherapy, identifying contribution by photons and electrons emmited from the source..

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Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages in therapeutic efficacy and safety have been the main target of interest. Its application in immune system prevention, stability in physiological environments and cell membranes, low toxicity and optimal bioperformances are critical to the success of engineered nanomaterials.

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New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of surfactants was described. The nuclear activated Gold-198 foils were transformed into HAuCl by dissolution using aqua regia, following a set of steps in a specially designed leak-tight setup.

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The present work described the cold fabrication of a P-32 radioactive source to be used in CNS cancer using epoxy resin. The epoxy plaque fabricated with Teflon mold presented better agreement. MCNP simulation evaluated the radiation dose.

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Article Synopsis
  • A new efficient method for creating iodine-based radioactive silver seed cores for brachytherapy is introduced, which minimizes reaction time and rework.
  • This method enables nearly complete deposition of iodine-131 on multiple silver substrates simultaneously, ensuring even distribution of radioactivity among the cores.
  • It generates minimal radioactive waste, contributing to the production of more affordable radioactive iodine seeds for use in brachytherapy treatments.
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