Publications by authors named "Maria Elena S Samson"
Upregulation of MYC is a common driver event in human cancers, and some tumors depend on MYC to maintain transcriptional programs that promote cell growth and proliferation. Preclinical studies have suggested that individually targeting upstream regulators of MYC, such as histone deacetylases (HDAC) and phosphoinositide 3-kinases (PI3K), can reduce MYC protein levels and suppress the growth of MYC-driven cancers. Synergy between HDAC and PI3K inhibition in inducing cancer cell death has also been reported, but the involvement of MYC regulation is unclear.
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- CUDC-101 is a new cancer-fighting drug that targets different proteins in cancer cells and is being tested on patients with solid tumors.
- It has shown strong effects in killing cancer cells and stopping their growth, even in cancer cells that are resistant to other treatments.
- The drug works by blocking certain signals and helping restore important proteins that keep cancer cells from spreading, which could help improve cancer treatment outcomes.
An understanding of the number and types of progeny produced by progenitor cells during development provides a foundation for studies of when and where cell fate determination takes place. Lineal relationships can be revealed by the identification of descendents of cells that express a recombinase, such as Cre or Flp. This method provides data concerning gene expression history, but does not provide clonal resolution among the descendents.
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