Survival of Mexican children with acute myeloid leukaemia who received early intensification chemotherapy and an autologous transplant.

Background: In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment.

[Diagnosis and treatment guideline for primary hypothyroidism in adulthood].

Our objective was to develop clinical guidelines based on the best clinical evidence to help the staff of medical setting of all levels (first, second and third medical attention levels) to provide evidence based care and diagnosis of hypothyroidism in adults nationwide. The guidelines were built using structured and relevant clinical questions. A strategy was developed to identify the main clinical guidelines for hypothyroidism in adult patient.

[Uncontrolled chronic glycaemia in diabetic patients with neoplasm increases the risk of early surgical complications].

Background: The effect of uncontrolled chronic glycemia (UCG) in the diabetic patient with a neoplasm (DPN) has not been evaluated during the early postoperative period. Our objective was to determine the frequency of early surgical complications in the DPN with UCG.

Methods: A cohort of 184 consecutive diabetic patients who had a histological malignant diagnosis were studied; they were matched with 184 non-diabetic controls by age, gender, neoplasm type and surgery, those who received chemotherapy or irradiation 30 days before surgery were excluded.

[Unsual clinical signs of primary hyperparathroidism].

Background: A growing number of patients with primary hyperparathyroidism (PHPT) are diagnosed in the absence of symptoms following routine biochemical screening. However, in some countries, overt manifestations and osteitis fibrosa cystica (OFC) still dominate the clinical profile of PHPT patients.

Methods: We retrospectively studied clinical and biochemical manifestations of 47 consecutive patients with primary hyperparathyroidism who were treated with parathyroidectomy from October 1993 to June 2005.