Tranexamic acid use in high-risk blood transfusion patients undergoing total hip replacement: a randomised controlled trial.

Introduction: We hypothesised that a single preoperative intravenous dose of tranexamic acid (TXA) is effective in patients who undergo total hip arthroplasty (THA) and are at high risk of blood transfusion (preoperative haemoglobin level <13.0 g/dL).

Methods: A prospective, randomised controlled study of 308 patients who underwent primary THA was conducted.