Publications by authors named "Maria Edvardsson"
Background/objective: Type 2 diabetes is a major risk factor for atherosclerotic disease. It is well agreed that the reactivity of diabetic platelets is increased but how platelet reactivity regulates is unknown. In our laboratory, density separated platelets have been investigated extensively and high- and low-density platelets circulate in an activated state.
View Article and Find Full Text PDFBackground: Strong agonist provocation in vitro creates small procoagulant platelets characterized by down-regulated fibrinogen receptors as judged from surface αβ activation specific antibody (PAC-1). They further show increased surface Annexin V (binds to platelet membrane phosphatidylserine), lysosomal-associated membrane protein 1 (LAMP-1) (indicates lysosomal release) and exhibit disturbed mitochondria integrity as estimated from mitochondrial transmembrane potential changes. We postulated that some circulating platelets activate continuously thereby forming procoagulant populations in vivo.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers measured these blood markers at the start, 6 months, and 1 year later in 167 elderly NHRs, most of whom were women.
- * Findings indicate that higher levels of C-reactive protein and interleukin-8 over the year were linked to shorter survival times, suggesting these markers could be important for assessing health in this population.
Article Synopsis
- Reference intervals are important for assessing disease but often exclude the elderly, so this study aimed to evaluate certain blood analytes in elderly individuals with varying health statuses.
- The study included 569 nursing home residents over 80 years old, divided into frail, moderately healthy, and healthy cohorts, with blood samples analyzed for albumin, ALT, AST, creatinine, and γ-GT levels.
- Results showed that various factors like daily activities, gender, and health conditions significantly influenced the levels of these analytes, highlighting the complexity of interpreting lab results for elderly patients.
Rationale, Aims And Objectives: Reference intervals provided by the laboratory are commonly established by measuring samples from apparently healthy subjects in the ages 18-65 years, excluding elderly individuals with chronic diseases and medication. The aim of our study was to establish whether current reference intervals for immune parameters and chemical biomarkers are valid for older individuals including those with chronic diseases, so-called frail elderly.
Methods: Data from our cohort of 138 non-infected nursing home residents (NHR), mean age 86.