Publications by authors named "Maria Eduarda Deluca Joao"
Article Synopsis
- Free-living amoebas, like Acanthamoeba castellanii, prey on fungi such as the Cryptococcus genus, which includes human pathogens that need nutrients to thrive inside immune cells.
- The ACA1_271600 gene in A. castellanii codes for a metal transporter that affects zinc availability, crucial for the virulence of cryptococcal cells, particularly in the presence of phagocytes.
- Silencing the ACA1_271600 gene in amoebas led to increased survival of cryptococcal strains, especially the zip1 mutant, suggesting that this gene helps regulate nutrient availability and may impact other biological functions that inhibit cryptococcal growth.
