Hepcidin is a key mediator of anemia of inflammation in Crohn's disease.

Unlabelled: Anemia often complicates the course of Inflammatory Bowel Disease (IBD). Hepcidin, a liver-produced peptide hormone, is a key mediator of anemia of chronic disease (ACD). We hypothesized that hepcidin is significantly elevated in anemic CD patients and that hepcidin may cause iron restriction and, therefore, mediate ACD.

Colorectal cancer screening and surveillance in Crohn's colitis.

Aims: To assess colonoscopic screening and surveillance for detecting neoplasia in patients with long-standing colonic Crohn's disease (CD).

Patients And Methods: Colonoscopy and biopsy records from patients with colonic CD were evaluated at the Cedars-Sinai Inflammatory Bowel Disease Center during a 17-year period (1992-2009).

Results: Overall, 904 screening and surveillance examinations were performed on 411 patients with Crohn's colitis (mean 2.