Synergistic impact of innate immunity hyper-activation and endothelial dysfunction on the magnitude of organ failure in the infection-sepsis continuum.

Objectives: Identifying host response biomarkers implicated in the emergence of organ failure during infection is key to improving the early detection of this complication.

Methods: Twenty biomarkers of innate immunity, T-cell response, endothelial dysfunction, coagulation, and immunosuppression were profiled in 180 surgical patients with infections of diverse severity (IDS) and 53 with no infection (nIDS). Those better differentiating IDS/nIDS in the area under the curve were combined to test their association with the sequential organ failure assessment score by linear regression analysis in IDS.

Clinical features and respiratory pathophysiology of COVID-19 patients ventilated in the prone position: a cohort study.

Introduction: There are few studies that have investigated the response to the prone position in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome (ARDS). We describe the characteristics and outcomes of those patients in a tertiary hospital in Spain.

Material And Methods: This is an observational study in consecutive, mechanically ventilated COVID-19 patients.

Perioperative use of angiotensin-converting-enzyme inhibitors and angiotensin receptor antagonists.

Study Objective: Clinical repercussions of perioperative treatment with ACEIs/ARBs.

Design: Systematic review according to PRISMA statement.

Setting: Perioperative period.