Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization.

Purpose: To study the activity of the novel anti-angiogenic compound AG3340 (Prinomastat), a selective inhibitor of matrix metalloproteases, in an animal model of retinal neovascularization.

Methods: C57BL/6J mice were used to produce oxygen-induced retinal neovascularization. Mice were exposed to room air from birth (P0) to postnatal 7 days (P7) and to hyperoxia (75% oxygen) for the next 5 days.

Effects of preoperative and postoperative epiretinal membranes on macular hole closure and visual restoration.

Objective: To investigate the effects of epiretinal membranes (ERMs) on macular hole surgical results and postoperative visual restoration.

Design: A subgroup analysis arising from a multicenter, controlled, randomized clinical trial.

Participants: Ninety-one phakic eyes with an idiopathic macular hole that underwent standard vitrectomy for macular hole repair with or without ERM peeling.