In Vitro Effect of Epigallocatechin Gallate on Heme Synthesis Pathway and Protoporphyrin IX Production.

Photodynamic therapy (PDT) treats nonmelanoma skin cancer. PDT kills cells through reactive oxygen species (ROS), generated by interaction among cellular O photosensitizer and specific light. Protoporphyrin IX (PpIX) is a photosensitizer produced from methyl aminolevulinate (MAL) by heme group synthesis (HGS) pathway.

Thymol as adjuvant in oncology: molecular mechanisms, therapeutic potentials, and prospects for integration in cancer management.

Cancer remains a global health challenge, prompting a search for effective treatments with fewer side effects. Thymol, a natural monoterpenoid phenol derived primarily from thyme (Thymus vulgaris) and other plants in the Lamiaceae family, is known for its diverse biological activities. It emerges as a promising candidate in cancer prevention and therapy.

Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights.

Gastric cancer (GC) ranks fifth globally in cancer diagnoses and third for cancer-related deaths. Chemotherapy with 5-fluorouracil (5-FU), a primary treatment, faces challenges due to the development of chemoresistance. Tumor microenvironment factors, including C-C motif chemokine receptor 3 (CCR3), can contribute to chemoresistance.

Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance.

Cytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in incidence and third in cancer-related mortality worldwide, making it a major public health issue. Recent studies have focused on the role these cytokines may play in GC associated with angiogenesis, metastasis, and chemoresistance, which are key factors that can affect carcinogenesis and tumor progression, quality, and patient survival.

Exploring the Genetic Diversity of Epstein-Barr Virus among Patients with Gastric Cancer in Southern Chile.

The Epstein-Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile.

Genome analysis suggests HTLV-1aA introduction in Chile related to migrations of ancestral indigenous populations.

The human T cell lymphotropic virus type 1 (HTLV-1), unlike other RNA viruses such as HIV, has a stable genome and has infected humans since remote times. Although the HTLV-1 infection is endemic in South America, there is scarce information about HTLV-1 in Chile and its history of introduction. This study assessed the genomic content of HTLV-1 from Chile and its relationship with HTLV-1 lineages circulating worldwide by phylogenetic reconstruction and dating analyses.

Genetic Patterns Found in the Nuclear Localization Signals (NLSs) Associated with EBV-1 and EBV-2 Provide New Insights into Their Contribution to Different Cell-Type Specificities.

The Epstein-Barr virus (EBV) is a globally dispersed pathogen involved in several human cancers of B-cell and non-B-cell origin. EBV has been classified into EBV-1 and EBV-2, which have differences in their transformative ability. EBV-1 can transform B-cells into LCL more efficiently than EBV-2, and EBV-2 preferentially infects T-cell lymphocytes.

Phylogenetic dating analysis of HTLV-1 from Chile suggests transmissions events related to ancient migrations and contemporary expansion.

Human T-cell lymphotropic virus type 1 (HTLV-1) is a globally-spread virus. It is estimated that there are about 5–10 million infected people in the world. HTLV is endemic in Chile, with higher seroprevalence among indigenous people.

Role of CC Chemokines Subfamily in the Platinum Drugs Resistance Promotion in Cancer.

Cancer is a significant medical issue, being one of the main causes of mortality around the world. The therapies for this pathology depend on the stage in which the cancer is found, but it is usually diagnosed at an advanced stage in which the treatment is chemotherapy. Platinum drugs are among the most commonly used in therapy, unfortunately, one of the main obstacles to this treatment is the development of chemoresistance, which is the ability of cancer cells to evade the effects of drugs.

Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance.

Fucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity of fucoidans and their similarity with other molecules such as glycosaminoglycan, which enable them to participation in diverse biological processes.

Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines.

Gastric cancer (GC) is a significant cancer-related cause of death worldwide. The most used chemotherapeutic regimen in GC is based on platinum drugs such as cisplatin (CDDP). However, CDDP resistance reduces advanced GC survival.

Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils.

Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play important roles in controlling cholesterol homeostasis and as regulators of inflammatory gene expression and innate immunity, by blunting the induction of classical pro-inflammatory genes. However, opposite data have also been reported on the consequences of LXR activation by oxysterols, resulting in the specific production of potent pro-inflammatory cytokines and reactive oxygen species (ROS).

Correlates of physical activity and inactivity in urban Mexican youth.

Objectives: To evaluate correlates of physical activity in Mexico City school youth.

Methods: A cross-sectional survey was conducted with 1,004 school youth (490 males and 514 females), 9-18 years of age resident in Mexico City. Age, height, body mass index (BMI), socioeconomic status (SES), time viewing television and playing video games (physical inactivity), and perceived sport/physical activity status of mother and father were evaluated as potential correlates of physical activity [Physical Activity Questionnaire (PAQ)].

Age and secular effects on muscular strength of indigenous rural adults in Oaxaca, Southern Mexico: 1978-2000.

Purpose: To evaluate age and secular changes in strength of rural Zapotec adults in Oaxaca between 1978 and 2000.

Methods: Grip strength, height and weight were measured in 1978 (n = 247, 19-82 years) and 2000 (n = 407, 19-89 years); 35 males and 52 females were measured in both years. MANCOVA was used for comparisons by age and year.

Community well-being and growth status of indigenous school children in rural Oaxaca, southern Mexico.

Objective: To evaluate the relationship between community well-being based on an index of marginalization and growth status of indigenous rural school children in Oaxaca.

Methods: Heights and weights of a cross-sectional sample of 11,454 children, 6-14 years, from schools for indigenous rural children (escuelas albergue) in 158 municipios in Oaxaca were measured in 2007. Tertiles of an index of marginalization were used to classify the 158 municipios into three categories of community well-being: lowest (highest marginalization), low, and moderate (lowest marginalization).

Secular change in muscular strength of indigenous rural youth 6-17 years in Oaxaca, southern Mexico: 1968-2000.

Objective: The study compared the grip strength of indigenous school youth 6-17 years of age in Oaxaca, southern Mexico, who were surveyed in 1968, 1978 and 2000.

Methods: Grip strength (Smedley/Stoelting) was measured to 0.5 kg in 1280 children and adolescent, 621 males and 659 females, in the three surveys.

Secular change in heights of indigenous adults from a Zapotec-speaking community in Oaxaca, southern Mexico.

Secular change in adult height of residents in a rural indigenous community in the Valley of Oaxaca was evaluated. Subjects were measured in 1971 (49 males, 26 females 19-70 years), 1978 (128 males, 124 females 19-82 years) and 2000 (155 males, 255 females 19-89 years). Heights were adjusted for estimated loss with age using two protocols; height at 21 years of age was also estimated.

Socioeconomic variation in the growth status of urban school children 6-13 years in Oaxaca, Mexico, in 1972 and 2000.

Socioeconomic variation in the growth status of urban school children 6-13 years of age in 1972 and 2000 was compared. The children were resident in the city of Oaxaca and were students in the same primary school in each year. Socioeconomic status (SES) was based on parental occupation.

Physical activity in youth from a subsistence agriculture community in the Valley of Oaxaca, southern Mexico.

Observations of activities of contemporary subsistence agricultural communities may provide insights into the lifestyle of youth of 2 to 3 generations ago. The purpose of this study was to document age- and sex-associated variation in household activities and daily steps walking to school of youth 9-17 years in an indigenous subsistence agricultural community in Oaxaca, southern Mexico. Activities during leisure were also considered.

Natural selection and demographic transition in a Zapotec-speaking genetic isolate in the Valley of Oaxaca, southern Mexico.

Objective: The study analyzed the potential for natural selection and the demographic transition in an isolated Amerindian population in the process of secular change in body size.

Setting: A genetically isolated, Zapotec-speaking community located in the Valley of Oaxaca, southern Mexico, has been studied regularly from the mid-1960s to 2000. Children, adolescents and young adults have experienced a recent secular increase in body size since 1978 after a major period of no change.

Overweight and obesity in a rural Amerindian population in Oaxaca, Southern Mexico, 1968-2000.

The purpose of this study was to evaluate secular change in the prevalence of overweight and obesity in a rural Zapotec Indian community in southern Mexico between 1968 and 2000. Cross-sectional surveys of children 6-13 years, adolescents 13-17 years, and adults 19 years of age and older resident in a rural community in Oaxaca were conducted in 1968/1971, 1978, and 2000. Individuals present in the 1968, 1978, and 2000 surveys provided a small longitudinal component.