Publications by authors named "Maria E Plokhotnichenko"
Article Synopsis
- Researchers studied the inhalation delivery of ceftriaxone in mice using an ultrasonic nebulizer, focusing on particle sizes between 0.5-1.5 μm and mass concentrations of 0.01-0.6 μg/cm.
- They measured ceftriaxone levels in the blood and lungs over time using high-performance liquid chromatography, with doses ranging from 3-5 mg/kg.
- The treatment showed high antibacterial effectiveness, resulting in improved survival rates for mice infected with specific bacteria after receiving the ceftriaxone aerosol.
Under pandemic-caused emergency, evaluation of the potential of existing antiviral drugs for the treatment of COVID-19 is relevant. Triazavirin, an antiviral drug developed in Russia for per-oral administration, is involved in clinical trials against SARS-CoV-2 coronavirus. This virus has affinity to epithelial cells in respiratory tract, so drug delivery directly in lungs may enhance therapeutic effect and reduce side effects for stomach, liver, kidneys.
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