Publications by authors named "Maria E Petrey"
Bioorg Med Chem Lett
November 2006
Article Synopsis
- The study focuses on the development of new compounds called N-sulfonyl-2-indole carboxamides that interact with PPAR-gamma, a receptor important for various biological functions.
- Through chemical optimization, a specific compound named 4q was found to have a strong binding affinity to PPAR-gamma, with an IC(50) value of 50 nM, indicating its potential effectiveness.
- Initial tests in cells suggest that these compounds could be useful in treating osteoporosis, a condition characterized by weak and brittle bones.
