Publications by authors named "Maria E Jimenez Martinez"
Article Synopsis
- Thirty-nine clinical isolates from 11 cystic fibrosis patients were analyzed over a 10-year period using whole genome sequencing (WGS) to study their genomic and phenotypic characteristics.
- A single, persistent strain was identified in a long-term patient, showing reduced elastase activity and growth rate, which suggests adaptive changes over time, with no instances of transmission between patients or centers.
- The study highlights unique genomic traits of the isolates, such as the conservation of biofilm and phenazine-related genes, and emphasizes the importance of integrating both genomic and virulence-related phenotypic testing in cystic fibrosis research.
Background: Ventilator-Associated pneumonia (VAP) is one of the leading causes of morbidity and mortality in critically ill COVID-19 patients in lower-and-middle-income settings, where timely access to emergency care and accurate diagnostic testing is not widely available. Therefore, rapid microbiological diagnosis is essential to improve effective therapy delivery to affected individuals, preventing adverse outcomes and reducing antimicrobial resistance.
Methods: We conducted a cross-sectional study of patients with suspected VAP and COVID-19, evaluating the diagnostic performance of the BioFire® FilmArray® Pneumonia Panel (FA-PP).
The susceptibility to 14 beta-lactam and non-beta-lactam antimicrobial agents was evaluated for Streptococcus pneumoniae from patients with community-acquired respiratory infections in a Mexican medical center. Three hundred fifteen pneumococcal isolates obtained from patients between 1995 and 2001 were tested by the broth microdilution test. Fifty-two percent of the isolates were nonsusceptible to penicillin (minimal inhibitory concentration, >0.
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