Synopsis of recent research by authors named "Maria E Engel"
Maria E Engel's recent research centers on the development and evaluation of in vitro genotoxicity assays, emphasizing a multiplexed approach that enhances the assessment of DNA damage and mutation.
One key study involves the interlaboratory evaluation of the MultiFlow DNA Damage Kit, which utilizes flow cytometric analysis to measure DNA damage markers such as p53 and γH2AX.
Another notable work compares the Pig-a mutation assay with traditional genotoxicity endpoints, focusing on the effects of ethyl methanesulfonate in a controlled 28-day study with male Sprague-Dawley rats.