Publications by authors named "Maria E Cabrera"
Article Synopsis
- Variations in access to drugs globally make it hard to assess the effectiveness of modern treatments for patients with relapsed and refractory mature T-cell and NK-cell lymphomas in a study of 925 patients.
- * The study found that relapsed lymphoma patients had better overall survival rates compared to refractory patients after second-line treatment, with several factors identified as predictors of survival.
- * A new prognostic index (PIRT) categorizes patients based on risk factors into low, intermediate, or high risk, impacting 3-year overall survival rates, and highlights the superior outcomes of novel therapies compared to traditional chemotherapy.
Article Synopsis
- Primary lymphoma of the female genital tract (PLFGT) is an uncommon type of lymphoma, with a study involving 60 women revealing that many cases were diagnosed around their early 50s.
- The uterus and ovaries were the most frequently affected sites, and diffuse large B-cell lymphoma (DLBCL) was the predominant subtype found in the majority of patients.
- The study indicated a median overall survival of approximately 13 years for DLBCL patients, with advanced disease stage correlating to a poorer prognosis, while CNS relapses were notably linked to patients with ovarian involvement who did not receive prophylactic treatment.
Article Synopsis
- Follicular lymphoma (FL) is the most common slow-growing non-Hodgkin lymphoma in the U.S. and Europe, but there's limited data from Latin America, particularly Chile.
- The study involved 722 Chilean patients diagnosed with FL from 2000 to 2019, revealing a median diagnosis age of 62, with many patients presenting advanced disease and a significant number affected by bone marrow involvement.
- Key findings show that adding rituximab to chemotherapy improves overall survival and response rate, while experiencing POD24 (progression of disease within 24 months) indicates much poorer survival outcomes.
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally.
View Article and Find Full Text PDFPurpose: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype. The purpose of this study was to evaluate the clinical features, prognostic factors, and results of DLBCL that was treated in the cancer centers of the public health system in Chile and compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).
Patients And Methods: Patients age > 15 years who were treated in 18 cancer centers in the country between 2001 and 2017 were included.
Article Synopsis
- The T-cell Lymphoma Project is a global study that examined clinical features and treatment outcomes of patients with newly diagnosed peripheral T-cell and NK-cell lymphomas, enrolling 1553 patients from 74 institutions across 14 countries between 2006 and 2018.
- Among the participants, 131 (8.4%) were identified with anaplastic large cell lymphoma - kinase positive (ALCL, ALK+), mostly in young adults with a median age of 39; many patients had advanced-stage disease but a majority had low-risk scores.
- Treatment with anthracycline chemotherapy yielded an 81% overall response rate, with 70% achieving complete remission, and three- and five-year overall survival rates
Background: Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).
Aim: To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile.
Article Synopsis
- Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic blood disorders marked by excessive production of myeloid blood cells, with major types being polycythemia vera (PV), essential thrombocytopenia (ET), and primary myelofibrosis (PMF).
- A study in Chile reviewed the medical records of 462 patients referred for MPN from 2012 to 2017, finding that ET was the most common type, with a reported incidence of 1.5 cases per 100,000 people.
- Despite extensive testing for the JAK2 V617F mutation, only 30% of patients underwent a bone marrow biopsy, and overall survival was 87
Article Synopsis
- Before tyrosine kinase inhibitors (TKIs) were introduced, patients with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ALL) had poor outcomes; the combination of TKIs with intense chemotherapy has significantly improved these results.
- A study conducted on 35 patients at a public hospital in Santiago, Chile, between 2010 and 2019 showed a 97% complete response rate, and 61% had no measurable residual disease (MRD) during follow-up.
- While the overall survival and event-free survival rates at three years were 52% and 34% respectively, achieving MRD negativity before three months did not significantly improve these outcomes, suggesting the combined treatment is an effective option for Ph+
Article Synopsis
- * The incidence rate was significantly lower in the Amerindian population (0.09/100,000) compared to the general Chilean population (1.17/100,000), with a median patient age of 73 years at diagnosis.
- * Overall survival (OS) at five years was 56%, with poorer outcomes observed in men, patients aged 65 and older, and those classified as high-risk, indicating lower incidence and worse
Introduction: Acute myeloid leukemia (AML) is a heterogeneous disease and approximately one-third of its carriers do not have evident genetic abnormalities. The mutation of specific molecular markers, such as fms-like tyrosine kinase 3 (FTL3) internal tandem duplication (ITD), FLT3 tyrosine kinase domain (TKD) and nucleophosmin (NPM1), are associated with an adverse and favorable prognosis, respectively.
Objective: The objective was to determine the prevalence of FLT3/ITD and NPM1 in Chilean patients and their association with clinical data and prognosis.
Article Synopsis
- People living with HIV (PLWH) continue to experience high rates of lymphoma-related morbidity and mortality, prompting this study in a Chilean public hospital.
- The study analyzed data from 84 PLWH diagnosed with different types of lymphoma between 2010 and 2017 and compared their survival rates to a previous cohort from 1992 to 2008.
- Overall survival improved in this more recent cohort, particularly for patients with diffuse large B-cell lymphoma (DLBCL), largely attributed to better access to antiretroviral therapy, despite no significant changes in chemotherapy treatments.
Article Synopsis
- Angioimmunoblastic T-cell lymphoma (AITL) is a serious subtype of peripheral T-cell lymphoma with distinct characteristics and a generally poor prognosis, affecting mostly older patients with advanced disease.
- A study analyzed data from 282 AITL patients over 12 years, finding a 5-year overall survival rate of 44% and a progression-free survival rate of 32%, with improved outcomes for those who received stem cell transplants.
- Key factors influencing survival included age, performance status, and specific lab markers, leading to the development of a new prognostic score that better distinguishes risk levels and highlights the need for more effective treatments.
Purpose: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease caused by the human T-cell leukemia virus type 1. Real-world data of ATLL in Latin America are lacking.
Patients And Methods: We analyzed patients with ATLL (acute, lymphomatous, chronic, and smoldering) encountered in 11 Latin American countries between 1995 and 2019.
Article Synopsis
- Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK- ALCL) is a type of aggressive cancer affecting T-cells, with a median diagnosis age of 54 and a majority of male patients (62%).
- Out of 1,553 cases studied globally, 71% were at advanced stages (III-IV), and 85% received multiagent chemotherapy, showing initial response rates of 77% overall and 63% complete.
- After a median follow-up of 52 months, progression-free survival was 41 months, and overall survival was 55 months, with treatments including anthracycline and etoposide yielding better overall survival outcomes.
Introduction: We aimed at investigating the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in 2 independent cohorts of Latin American patients with diffuse large B-cell lymphoma (DLBCL) treated with chemoimmunotherapy.
Patients And Methods: The learning cohort was composed of 274 patients and the validation cohort of 323 patients, for a total of 597 patients. An optimal NLR cutoff ≥ 4 was determined using receiver operating characteristic analysis.
Telementoring platforms can help transfer surgical expertise remotely. However, most telementoring platforms are not designed to assist in austere, pre-hospital settings. This paper evaluates the system for telementoring with augmented reality (STAR), a portable and self-contained telementoring platform based on an augmented reality head-mounted display (ARHMD).
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- Extranodal natural killer (NK) T-cell lymphoma (ENKTL) is a rare cancer associated with poor survival rates, predominantly studied in East Asian populations, leaving a gap in international data on treatment outcomes.
- This research is part of the T-cell Project, which tracked newly diagnosed NK and T-cell lymphoma patients from 13 countries, enrolling 1,695 participants and focusing on patient characteristics and survival rates over time.
- The study found that 5-year overall survival rates were 54% for patients with nasal ENKTL and 34% for those with extranasal disease, representing the largest global dataset on ENKTL and highlighting significant improvements in patient survival with routine treatment practices.
Introduction: Point-of-injury (POI) care requires immediate specialized assistance but delays and expertise lapses can lead to complications. In such scenarios, telementoring can benefit health practitioners by transmitting guidance from remote specialists. However, current telementoring systems are not appropriate for POI care.
View Article and Find Full Text PDFElectroencephalography (EEG) activity in the mu frequency band (8-13 Hz) is suppressed during both gesture performance and observation. However, it is not clear if or how particular characteristics within the kinematic execution of gestures map onto dynamic changes in mu activity. Mapping the time course of gesture kinematics onto that of mu activity could help understand which aspects of gestures capture attention and aid in the classification of communicative intent.
View Article and Find Full Text PDFBackground: The surgical workforce particularly in rural regions needs novel approaches to reinforce the skills and confidence of health practitioners. Although conventional telementoring systems have proven beneficial to address this gap, the benefits of platforms of augmented reality-based telementoring in the coaching and confidence of medical personnel are yet to be evaluated.
Methods: A total of 20 participants were guided by remote expert surgeons to perform leg fasciotomies on cadavers under one of two conditions: (1) telementoring (with our System for Telementoring with Augmented Reality) or (2) independently reviewing the procedure beforehand.
Introduction: The evaluation of memory has increased relevance because of the place occupied by its alterations in neuropsychological syndromes of wide prevalence. The TAVEC evaluates strategies and processes involved in learning and remembering of verbal material.
Objective: Generate normative data of the TAVEC for the adult population of Córdoba (Argentina) with high level of instruction.
The concept "Biobank" is relatively new in the scientific literature, and is not yet consensually defined, even for the World Health Organization (WHO). However, the use of human samples in biomedical research is a very old activity. The organized development of Biobanks in different places has grown in the last decade.
View Article and Find Full Text PDFThe T Cell Project was the largest prospective trial to explore the incidence, treatment patterns, and outcomes for T cell lymphomas. The rare subtypes of T cell lymphomas, including hepatosplenic T cell lymphoma (HSTCL), enteropathy associated T cell lymphoma (EATL), and peripheral gamma delta T cell lymphomas (PGDTCLs) are poorly represented in most studies and there is little data regarding treatment patterns. We report results from 115 patients with hepatosplenic (n = 31), enteropathy associated (n = 65), and PGDTCLs (n = 19).
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