Publications by authors named "Maria Dunia Roldan-Diaz"
Article Synopsis
- Early breast cancer patients often relapse due to leftover cancer cells after treatment, and traditional methods struggle to detect them in low concentrations.
- A study collected 282 high-volume blood samples to improve the detection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) using a specialized PCR assay, successfully finding ctDNA and/or CTCs in all pre-treatment samples.
- The method showed promise for predicting residual disease accurately and detecting relapses months in advance, making it a potentially effective tool for monitoring early breast cancer patients post-treatment.
Background: Analysis of circulating tumor DNA (ctDNA) is increasingly used for clinical decision-making in oncology. However, ctDNA could represent ≤ 0.1 % of cell-free DNA in early-stage tumors and its detection requires high-sensitive techniques such as digital PCR (dPCR).
View Article and Find Full Text PDFBreast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. Herein, we developed a novel ultrasensitive pipeline to detect circulating tumor DNA (ctDNA) in a series of 75 plasma samples from localized BC patients prior to any medical intervention.
View Article and Find Full Text PDF