Hospital Environment as a Source of Azole-Resistant Strains with TR34/L98H and G448S Cyp51A Mutations.

Azole-resistant is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant hospital colonization in a patient is reported here. Investigations of the hospital environment led to the recovery of strains harboring the TR34/L98H and the G448S Cyp51A azole resistance mechanisms.