Publications by authors named "Maria Dolores Marti"
Vulvar high-grade squamous intraepithelial lesion (vulvar HSIL) or vulvar intraepithelial neoplasia (VIN) is a premalignant condition that can progress to carcinoma. Imiquimod is a topical drug with high effectiveness and low morbidity. We aimed (1) to assess the long-term response to imiquimod in a cohort of patients with vulvar HSIL and (2) and to analyze the role of HPV determined in pre- and post-imiquimod treatment biopsies in the persistence or recurrence of vulvar HSIL.
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- * A study compared two groups of patients: one receiving standard wound closure and the other receiving closed-incisional negative pressure therapy (ciNPT) during surgery, revealing a substantial reduction in complications (6.9% with ciNPT vs. 31.8% with standard closure).
- * Results showed that ciNPT not only lowered infection rates and other complications but also reduced hospital stays, suggesting it should be considered for patients at high risk of wound issues.
Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease relapse. Dissecting adaptive mechanisms is of vital importance to circumvent clinical drug resistance and improve the efficacy of targeted agents in EC. Sorafenib is an FDA-approved multitarget tyrosine and serine/threonine kinase inhibitor currently used to treat hepatocellular carcinoma, advanced renal carcinoma and radioactive iodine-resistant thyroid carcinoma.
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