Publications by authors named "Maria Dolores Garcia-Cosio Carmena"
Background: Cytomegalovirus (CMV) infection is associated with worse outcomes after heart transplant (HT). CMV mismatch (donor positive, recipient negative serology, D+/R-) increases the risk of infection. Guidelines recommend 3 to 6 months of antiviral prophylaxis in these patients.
View Article and Find Full Text PDFBackground: There is a long-standing need for a noninvasive biomarker that allows monitoring of cardiac allograft rejection, avoiding the need for periodic endomyocardial biopsies (EMB).
Methods: Multicenter, observational, prospective study, performed between 2019 and 2023 (NCT04973943). All patients underwent 7 per-protocol surveillance EMB during the first postheart transplantation year.
Article Synopsis
- * A total of 245 patients were analyzed, with 54.3% using mechanical LV unloading techniques, primarily the intra-aortic balloon pump, showing an improved 1-year survival rate of 74.4% compared to 59.8% in those without LV unloading.
- * The findings suggest that preoperative LV unloading is linked to better survival rates after a year post-transplant, with no notable differences in other postoperative complications between groups.
Purpose Of Review: Limited research has been conducted on sex disparities in heart transplant (HT). The aim of this review is to analyse the available evidence on the influence of sex and gender-related determinants in the entire HT process, as well as to identify areas for further investigation.
Recent Findings: Although women make up half of the population affected by heart failure and related mortality, they account for less than a third of HT recipients.
Article Synopsis
- Heart transplant recipients (HTr) are at greater risk for severe COVID-19, and a study analyzed their prognosis over the pandemic from February 2020 to October 2022.* -
- Among 308 HTr studied, 39.2% were infected; those with pneumonia had significantly worse outcomes, with higher hospitalization and death rates compared to less severe cases.* -
- Improvements in prognosis were noted over time, with reduced pneumonia (from 62% to 19%) and mortality (from 23% to 4%), attributed to factors like vaccination and early remdesivir treatment.*
Antibodies directed against donor-specific human leukocyte antigens (HLAs) can be detected de novo after heart transplantation and play a key role in long-term survival. De novo donor-specific antibodies (dnDSAs) have been associated with cardiac allograft vasculopathy, antibody-mediated rejection, and mortality. Advances in detection methods and international guideline recommendations have encouraged the adoption of screening protocols among heart transplant units.
View Article and Find Full Text PDFIntroduction And Objectives: Repetitive ambulatory doses of levosimendan are an option as a bridge to heart transplantation (HT), but evidence regarding the safety and efficacy of this treatment is scarce. The objective of the LEVO-T Registry is to describe the profile of patients on the HT list receiving levosimendan, prescription patterns, and clinical outcomes compared with patients not on levosimendan.
Methods: We retrospectively reviewed all patients listed for elective HT from 2015 to 2020 from 14 centers in Spain.
Use of a surgically implanted, nondischargeable, extracorporeal continuous flow circulatory support system as a bridge to heart transplant.
Rev Esp Cardiol (Engl Ed)
January 2024
Introduction And Objectives: We aimed to describe the clinical outcomes of the use of the CentriMag acute circulatory support system as a bridge to emergency heart transplantation (HTx).
Methods: We conducted a descriptive analysis of the clinical outcomes of consecutive HTx candidates included in a multicenter retrospective registry who were treated with the CentriMag device, configured either for left ventricular support (LVS) or biventricular support (BVS). All patients were listed for high-priority HTx.
Temporal trends in the use and outcomes of temporary mechanical circulatory support as a bridge to cardiac transplantation in Spain. Final report of the ASIS-TC study.
J Heart Lung Transplant
April 2023
Background: We aimed to describe recent trends in the use and outcomes of temporary mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx) in Spain.
Methods: Retrospective case-by-case analysis of 1,036 patients listed for emergency HTx while on temporary MCS in 16 Spanish institutions from January 1st, 2010 to December 31st, 2020. Patients were classified in 3 eras according to changes in donor allocation criteria (Era 1: January 2010/May 2014; Era 2: June 2014/May 2017; Era 3: June 2017/December 2020).
Rationale and Protocol of the Multimodality Evaluation of Antibody-Mediated Injury in Heart Transplantation (LEONE-HT) Observational Cross-Sectional Study.
Methods Protoc
September 2022
Article Synopsis
- - The LEONE-HT study investigates the poor heart transplant (HT) survival rates and the role of anti-HLA antibodies, which may cause cardiac allograft dysfunction in patients receiving heart transplants.
- - It involves a cohort of HT patients, comparing those with positive anti-HLA antibodies to those without, utilizing advanced assessment methods like imaging and immunological analyses to understand the extent of myocardial damage.
- - Ethical standards for the study are met, adhering to global guidelines, and findings will be shared through patient associations and registered on clinicaltrials.gov for transparency.
Introduction And Objectives: This report presents the clinical characteristics, outcomes and complications of all consecutive patients implanted with a long-term mechanical circulatory support device in Spain between 2007 and 2020.
Methods: Analysis of the Spanish Registry of durable ventricular assist devices (REGALAD) including data form Spanish centers with a mechanical circulatory support program.
Results: During the study period, 263 ventricular assist devices were implanted in 22 hospitals.
Article Synopsis
- - Telemonitoring using cardiac devices, like the HeartLogic algorithm from Boston Scientific, can enhance follow-up care for heart failure patients by tracking various health metrics, such as heart rate and physical activity.
- - The HeartLogic algorithm monitors factors such as nocturnal heart rate and thoracic impedance to predict serious health events, showing high sensitivity in detecting heart failure issues.
- - Despite promising detection abilities, the impact of HeartLogic on hospitalizations and mortality rates has not yet been confirmed in clinical trials, prompting a review of its functionality and real-world application.
Spain is a world leader in donation and transplantation. This model has been exported to other countries with favorable results. The objective of this study was to compare the actual donation intention rate with the effective donation figures, and analyze the main reasons why families decline organ donation.
View Article and Find Full Text PDFBackground: Poor natriuresis has been associated with a poorer response to diuretic treatment and worse prognosis in acute heart failure. Recommendations on how and when to measure urinary sodium (UNa) are lacking. We aim to evaluate UNa quantification after a furosemide stress test (FST) capacity to predict appropriate decongestion during acute heart failure hospitalization.
View Article and Find Full Text PDFIntroduction And Objectives: Bosentan has proven efficacy in pulmonary hypertension in the short term. Little is known about its effects beyond 2 to 3 years. Our objective was to analyze the efficacy and safety of bosentan in the long term (5 years) in patients treated in our center.
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