Publications by authors named "Maria Dodina"
Evaluation of mesenchymal stem cells as an model for inherited retinal diseases.
Front Cell Dev Biol
November 2024
Article Synopsis
- Retinal pathologies, particularly inherited retinal diseases (IRDs) like retinitis pigmentosa, are key contributors to vision impairment and blindness, necessitating effective research models for understanding and developing treatments.
- Various types of cells, including retina-specific cell lines, primary retinal cells, and mesenchymal stem cells (MSCs), can be utilized to create models of IRDs, with a focus on MSCs due to their effective differentiation into retinal cells.
- MSC-based models offer advantages over induced pluripotent stem cell (iPSC) models, being cheaper and quicker for drug screening purposes; however, the methods for differentiation still require optimization for better results.
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, safety, and immunogenicity of the inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 and open multi-center comparative phase IIb clinical trial in volunteers aged 60 years and older. The safety of the vaccine was assessed in 400 volunteers in the 18-60 age cohort who received two doses of the vaccine (n = 300) or placebo (n = 100) and in 200 volunteers in 60+ age cohort all of whom received three doses of the vaccine. The studied vaccine has shown good tolerability and safety.
View Article and Find Full Text PDFThe goal was to determine ways to optimize diagnostic and therapeutic measures for various types of melasma in the outpatient setting of the dermatovenerological ambulatory clinic. The study involved 112 women with a confirmed diagnosis of facial melasma whose disease lasted for at least 2 years. The severity of patient pigmentation was evaluated using the Melasma Area Severity Index and the Melasma Severity Scale.
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