Publications by authors named "Maria Dinu"

Objectives: The main objectives were to investigate the prevalence of ED and associated risk factors among medical students in Romania, as well as to determine which variables may predict ED and to explore the differences between medical students and the general population.

Methods: The Eating Disorders Inventory questionnaire (EDI-3) was applied. Also, the body mass index of the students was calculated, socio-demographic information regarding personal and family medical history was collected (mental and chronic diseases, self-reported sleep difficulties in the past 6 months, family history of obesity) and potentially risky events (history of ridicule, major negative events, social pressure to be thin from family, friends, media).

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Conductive hydrogels are an appealing class of "smart" materials with great application potential, as they combine the stimuli-responsiveness of hydrogels with the conductivity of magnetic fillers. However, fabricating multifunctional conductive hydrogels that simultaneously exhibit conductivity, self-healing, adhesiveness, and anti-freezing properties remains a significant challenge. To address this issue, we introduce here a freeze-thawing approach to develop versatile, multiresponsive composite cryogels able to preserve their features under low-temperature conditions.

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Bacterial contamination is a major public health concern on a global scale. Treatment resistance in bacterial infections is becoming a significant problem that requires solutions. We were interested in obtaining new polymeric functionalized compounds with antibacterial properties.

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Porous hydrogels have brought more advantages than conventional hydrogels when used as chromatographic materials, controlled release vehicles for drugs and proteins, matrices for immobilization or separation of molecules and cells, or as scaffolds in tissue engineering. Polysaccharide-based porous hydrogels, in particular, can address challenges related to bioavailability, solubility, stability, and targeted delivery of natural antioxidant compounds. Their porous structure enables the facile encapsulation and controlled release of these compounds, enhancing their therapeutic effectiveness.

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Polysaccharides have recently attracted growing attention as adsorbents for various pollutants, since they can be extracted from a variety of renewable sources at low cost. An interesting hydrophilic and biodegradable polysaccharide is dextran (Dx), which is well-known for its applications in the food industry and in medicine. To extend the application range of this biopolymer, in this study, we investigated the removal of crystal violet (CV) and methylene blue (MB) dyes from an aqueous solution by Dx-based cryogels using the batch technique.

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This study focuses on the development of adsorptive materials to retain degraded 5w40 motor oil. The materials were prepared using xanthan (XG) and XG esterified with acrylic acid (XGAC) as the polymeric matrix. LignoBoost lignin (LB), LB esterified with oleic (LBOL), stearic acid (LBST) and montmorillonite (CL) were added into XG and XGAC matrices to obtain the adsorbents.

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Biobased porous hydrogels enriched with phytocompounds-rich herbal extracts have aroused great interest in recent years, especially in healthcare. In this study, new macroporous hybrid cryogel constructs comprising thiourea-containing chitosan (CSTU) derivative and a L. extract (HYP), commonly known as St John's wort, were prepared by a facile one-pot ice-templating strategy.

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Article Synopsis
  • Polysaccharides like chitosan and alginate have been used to create versatile hydrogels that can improve the effectiveness of drug delivery and functional foods.
  • These hydrogels help resolve issues related to bioavailability, solubility, stability, and targeted delivery of phytocompounds.
  • The review discusses the preparation, properties, and applications of these hybrid systems, particularly in areas like wound management and the food industry, emphasizing how their structural and functional requirements impact their performance.
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In this study, a new strategy was adopted for obtaining polymer/protein hybrid hydrogels with shape stability and tunable mechanical or rheological characteristics by using non-toxic procedures. A chemical network was created using a poly(vinyl alcohol)(PVA)/bovine serum albumin (BSA) mixture in aqueous solution in the presence of genipin and reduced glutathione (GSH). Then, a second physical network was formed through PVA after applying freezing/thawing cycles.

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Article Synopsis
  • The study focuses on hydroxypropyl cellulose (HPC), a water-soluble cellulose derivative, and explores its reaction to selective oxidation methods targeting its hydroxyl (OH) groups.
  • The oxidation processes involve two main techniques using various reagents like TEMPO and sodium periodate, with results measured for the formation of aldehydes and carboxylic groups.
  • The researchers also analyzed the chemical structure, crystallinity, and thermal stability of the oxidized HPC using advanced techniques like Fourier-transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis.
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  • Environmental contamination from pesticides is a widespread issue, creating a need for effective and eco-friendly removal methods.
  • The study explored the use of self-assembled hydrogels made from chitosan and carboxymethylcellulose, showing high efficiency in removing various fungicides, especially with the DA-CMC variant.
  • The results demonstrated that the CS/DA-CMC hydrogels could effectively reduce pesticide levels in water, achieving removal rates up to 94% for specific fungicides.
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The use of polysaccharides with good film-forming properties in food packaging systems is a promising area of research. Xanthan gum (XG), an extracellular polysaccharide, has many industrial uses, including as a common food additive (E415). It is an effective thickening agent, emulsifier, and stabilizer that prevents ingredients from separating.

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Article Synopsis
  • The study focused on creating new formulations using dextran and chitosan, incorporating various bioactive fillings like ginger extract and citric acid, which were characterized through advanced analytical techniques.
  • The formulations were evaluated for their antioxidant and anti-inflammatory properties, finding that ginger and other substances can effectively reduce inflammation and oxidative stress.
  • Results showed that adding these active ingredients enhanced both mechanical strength and antioxidant capabilities, suggesting potential medical applications for repairing cell membranes and improving enzyme activities.
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This study aimed to evaluate the effect of the synthesis parameters and the incorporation of natural polyphenolic extract within hydrogel networks on the mechanical and morphological properties of physically cross-linked xanthan gum/poly(vinyl alcohol) (XG/PVA) composite hydrogels prepared by multiple cryo-structuration steps. In this context, the toughness, compressive strength, and viscoelasticity of polyphenol-loaded XG/PVA composite hydrogels in comparison with those of the neat polymer networks were investigated by uniaxial compression tests and steady and oscillatory measurements under small deformation conditions. The swelling behavior, the contact angle values, and the morphological features revealed by SEM and AFM analyses were well correlated with the uniaxial compression and rheological results.

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The introduction of selective recognition sites toward certain heavy metal ions (HMIs) is a great challenge, which has a major role when the separation of species with similar physicochemical features is considered. In this context, ion-imprinted polymers (IIPs) developed based on the principle of molecular imprinting methodology, have emerged as an innovative solution. Recent advances in IIPs have shown that they exhibit higher selectivity coefficients than non-imprinted ones, which could support a large range of environmental applications starting from extraction and monitoring of HMIs to their detection and quantification.

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Heparin (Hep), with its anticoagulant activity, antiangiogenic and apoptotic effects, and growth factor binding, plays an important role in various biological processes. Formulations as drug delivery systems protect its biological activity, and limit the potential side effects of faulty administration. The objective of this study was to develop novel xanthan-based materials as a delivery carrier for heparin.

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Biomass-derived materials with multiple features are seldom reported so far. Herein, new chitosan (CS) sponges with complementary functions for point-of-use healthcare applications were prepared by glutaraldehyde (GA) cross-linking and tested for antibacterial activity, antioxidant properties, and controlled delivery of plant-derived polyphenols. Their structural, morphological, and mechanical properties were thoroughly assessed by Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and uniaxial compression measurements, respectively.

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Designing of economically feasible and recyclable polysaccharide-based materials with thiourea functional groups for removal of specific metal ions such as Ag(I), Au(I), Pb(II) or Hg(II) remains a major challenge for environmental applications. Here, we introduce ultra-lightweight thiourea-chitosan (CSTU) aerogels engineered by combining successive freeze-thawing cycles with covalent formaldehyde-mediated cross-linking and lyophilization. All aerogels exhibited outstanding low densities (0.

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It is still a challenge to develop advanced materials able to simultaneously remove more than one pollutant. Exclusive cationic composite double- and triple-network cryogels, with adequate sustainability in the removal of CrO and HPO oxyanions, were developed in this work starting from single-network (SN) sponges. Chitosan (CS), as the only polycation originating from renewable resources, and poly(N,N-dimethylaminoethylmethacrylate) (PDMAEMA) and polyethyleneimine (PEI), as synthetic polycations, were employed to construct multi-network cationic composite cryogels.

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Nowadays, pollution has become the main bottleneck towards sustainable technological development due to its detrimental implications in human and ecosystem health. Removal of pollutants from the surrounding environment is a hot research area worldwide; diverse technologies and materials are being continuously developed. To this end, bio-based composite hydrogels as sorbents have received extensive attention in recent years because of advantages such as high adsorptive capacity, controllable mechanical properties, cost effectiveness, and potential for upscaling in continuous flow installations.

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The paper reports on the performances of cross-linked amidoxime hosted into mesoporous silica (AMOX) in the removal of As(III) and As(V). The optimum pH for sorption of As(III) and As(V) was pH 8 and pH 5, respectively. The PFO kinetic model and the Sips isotherm fitted the best the experimental data.

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This study presents new drug delivery systems based on xanthan, unmodified or modified by esterification with oleic acid, and alginate for controlled release of bioactive substances with anti-inflammatory (piroxicam) and antifungal properties (ketoconazole). The mechanical properties of the developed drug carriers showed that their compressive strength was affected by the encapsulation of the bioactive principles. When ketoconazole was added into the xanthan/alginate matrix, an increment in the mechanical strength was recorded (66.

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Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-linking. A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontaneous interactions between CS and natural or synthetic biocompatible polyanions. PECs with tunable structures, morphologies, and mechanical properties were fabricated in this paper by an innovative and sustainable strategy.

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Article Synopsis
  • A series of experiments demonstrated the effectiveness of APCA-functionalized adsorbents for removing specific heavy metal ions in a batch setting, suggesting the need for further column studies for practical applications.
  • The sorption preference for heavy metals in a fixed-bed column showed that Ni2+ had the highest affinity for the sorbent, while Co2+ had the lowest, with a calculated maximum sorption capacity of 145.55 mg/g for the best-performing composite sorbent.
  • Successful desorption of heavy metals was achieved using a mild 0.1 M HCl solution, and theoretical analyses revealed that minimal energy is needed to favorably configure the APCA sorbents for optimal metal binding.
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