Direct action of triiodothyronine on gene expression in the neonatal brain and cerebellum.

Thyroid hormones play a major role in the development and function of several organs, especially the brain. The actions of thyroid hormones are exerted through the interaction of T3 with nuclear receptors and regulation of gene expression. The present study analyzed the effects of hypothyroidism and T3 administration on gene expression in the rat brain and cerebellum during the postnatal period.