Reducing Dental Anxiety in Children Using a Mobile Health App: Usability and User Experience Study.

Background: Dentistry interventions cause common anxiety and fear problems in children (6-11 years), and according to scientific evidence, this causes a decrease in their quality of life. Therapies mediated by IT-based tools have been shown to positively influence children's mood based on distraction as well as relaxing activities, but there is no evidence of their use to reduce dental anxiety in children.

Objective: The aim of this study was to answer the following research question: Does our new children-centered codesign methodology contribute to achieving a usable mobile-based product with a highly scored user experience?

Methods: A mobile health app was developed to reduce dental anxiety in children using rapid application development following the usage-centered design methodology.

Medicinal Plants with Anti-dengue and Immunomodulatory Activity.

Dengue fever is a disease with a high mortality rate around the world, which is an important issue for the health authorities of many countries. As a result of this, the search for new drugs that are effective to combat this disease has become necessary. Medicinal plants have been used since ancient times to treat a wide list of diseases, including dengue fever.

A cross sectional study of Mexican caregiver social status, dental knowledge, self-efficacy, and caregiver/child oral health. A structural equation model.

Objectives: To test hypothetical models relating caregivers' social status, knowledge, and self-efficacy to caregiver/child (C/C) oral health-related outcomes.

Methods: One hundred fifty C/C pairs participated (recruitment = 87.7 percent).

Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens.

Background: Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions.

Methods: Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemical or physical signal transmits through a cell as series of molecular events so the pathogen needs to intercept these molecular pathways at few positions to induce pathogenesis such as pathogen viability, infection or hypersensitivity.

An online survey detected knowledge gaps and cost-saving opportunities in asthma maintenance treatment among allergists, pulmonologists, ENTs and primary care.

Background: In April 2017 the Mexican Asthma Guidelines (GUIMA) were published. Before the launch, physicians' knowledge was explored related to key issues of the guideline.

Methods: A SurveyMonkey® survey was sent out to board-certified physicians of 5 medical specialties treating asthma.

An Open Label Study of an Occlusive Heat Patch in the Treatment of Warts.

Background: Local hyperthermia has been demonstrated to be a safe and efficacious treatment for warts. Objective: We aimed to evaluate the safety and efficacy of an epicutaneous heat patch to induce local hyperthermia for the treatment of warts. Methods: We performed an uncontrolled, proof of concept study by applying a novel, reproducible, epicutaneous heat patch to a target wart for 2 hours per day for 12 weeks.

Adsorption of organophosphorus pesticides in tropical soils: The case of karst landscape of northwestern Yucatan.

This article discusses the adsorption of four organophosphorus pesticides-diazinon, dimethoate, methyl parathion, and sulfotep-in soil samples from four sites-Komchén, Xcanatún, Chablekal and Mocochá- in the northwest of Yucatan, Mexico. These pesticides have been detected in groundwater at concentrations greater than 5 (μg/L) during recent monitoring campaigns in the study area. In this region, groundwater contamination is exacerbated by its karst aquifer, which is susceptible to contamination and is considered very vulnerable.

Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.

In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selectivity of ligands for G-protein coupled receptors, and that signaling by these receptors involves both G-protein dependent and independent pathways. The present review outlines the physiological and pharmacological implications of this perspective for the design of new drugs to treat disorders of the central nervous system.

Mechanism of the relaxant effect of rosuvastatin lactone on rat aortic rings.

The relaxant effect of the lactone of rosuvastatin was evaluated on aortic rings from male Wistar rats (250-300 g) with and without endothelium, precontracted with 1.0 microM phenylephrine. The lactone presented a greater potency than rosuvastatin in relaxing aortic rings.

MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients.

Background And Purpose: In a previous report, a strong gene-environment interaction between human herpesvirus 6A (HHV6A) active replication and MHC2TA rs4774C was demonstrated. The objectives of this study were: (i) to reappraise the association that was found in the previous study; (ii) to evaluate if MS patients with minor allele C and HHV-6A active infection had different clinical behavior; and (iii) to analyze the possible association of MHC2TA rs4774C with Epstein-Barr virus (EBV).

Methods: A total of 149 MS patients were analyzed both at the MHC2TA locus and by HHV-6A status in serum.

Isonymic relationships in ethno-social categories (Argentinian colonial period) including illegitimate reproduction.

Surnames provide a useful method to study the structure of human populations for which biological data are not available. The isonymic method has had multiple applications, but difficulties emerge when dealing with groups where extramarital reproduction is common and the sample size is small, and even more so when only paternal surnames are taken into account.Therefore, it could be of interest to retain female surnames, including those of unmarried mothers.

Greenlandic family structure and communication with parents: influence on schoolchildren's drinking behaviour.

Objectives: The objective of this paper is to investigate how changes in the Greenlandic family structure and perceived difficulties in communicating with parents affect the prevalence of alcohol consumption and the risk of drunkenness among schoolchildren.

Study Design: The survey was carried out in February 1998 in all schools in Greenland in the context of the WHO Health Behaviour in School-Aged Children (HBSC) study. Altogether 3,081 questionnaires were returned, which gave a response rate of 68% of the total study population.