Publications by authors named "Maria Deichner"
The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis.
Matthew John Eastham Andria Pelava Graeme Raymond Wells Justine Katherine Lee Isabella Rachel Lawrence Maria Deichner
Nucleic Acids Res
September 2023
Ribosome biogenesis is one of the biggest consumers of cellular energy. More than 20 genetic diseases (ribosomopathies) and multiple cancers arise from defects in the production of the 40S (SSU) and 60S (LSU) ribosomal subunits. Defects in the production of either the SSU or LSU result in p53 induction through the accumulation of the 5S RNP, an LSU assembly intermediate.
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- The study focused on developing an enzyme-linked immunosorbent assay (ELISA) to accurately detect antibodies against SARS-CoV-2, which is crucial for monitoring the pandemic and informing public health strategies.
- The ELISA utilized specific components of the virus (receptor-binding domain and spike ectodomain) and showed high specificity (99.3%) and sensitivity for different antibody types (IgM, IgA, IgG) in patient serum samples.
- The results indicated that this test can reliably assess immune response after infection and vaccination, making it valuable for understanding protective immunity in the population.