Publications by authors named "Maria Daniele Teixeira Beltrao de Lemos"
Article Synopsis
- Previous research indicates that being overweight or obese can disrupt brain function during critical developmental phases, but more studies are needed on how immediate overnutrition affects serotonin in the brain.
- This study investigates how altering serotonin levels with fluoxetine treatment in overnourished rats impacts oxidative stress and inflammatory markers in their brainstem and hypothalamus.
- Findings suggest that overnutrition in early life leads to harmful changes in brain chemistry, but fluoxetine treatment can counteract some of these negative effects, supporting healthier brain development.
Effects of fluoxetine withdrawal in the brainstem and hypothalamus of overnourished rats: Chronic modulation on oxidative stress levels.
Int J Dev Neurosci
May 2023
Poor nutritional quality in the early stages of development is associated with neurological diseases in adulthood. Studies showed that obesity-induced oxidative stress contributes to the genesis of neurological diseases through dysregulation of the brainstem and hypothalamus. Fluoxetine (Fx) is an antidepressant member in the family of selective serotonin reuptake inhibitors (SSRI) that can induce positive effects by reducing oxidative damage in brain tissues.
View Article and Find Full Text PDFNeonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats.
Nutr Neurosci
January 2024
Objectives: This study aims to assess the effect of neonatal treatment with kaempferol on neuromotor development, proliferation of neural precursor cells, the microglia profile, and antioxidant enzyme gene expression in the hippocampus.
Methods: A rat model of cerebral palsy was established using perinatal anoxia and sensorimotor restriction of hindlimbs during infancy. Kaempferol (1 mg/ kg) was intraperitoneally administered during the neonatal period.