The Genetic Research in Alzheimer Disease (GERALD) Initiative Finds rs9320913 as a Neural eQTL of lincRNA AL589740.1.

Alzheimer's disease is the most common cause of dementia worldwide, and longitudinal studies are crucial to find the factors affecting disease development. Here, we describe a novel initiative from southern Spain designed to contribute in the identification of the genetic component of the cognitive decline of Alzheimer's disease patients. The germline variant rs9320913 is a C>A substitution mapping within a gene desert.

Modeling Wording Effects Does Not Help in Recovering Uncontaminated Person Scores: A Systematic Evaluation With Random Intercept Item Factor Analysis.

The item wording (or keying) effect consists of logically inconsistent answers to positively and negatively worded items that tap into similar (but polarly opposite) content. Previous research has shown that this effect can be successfully modeled through the random intercept item factor analysis (RIIFA) model, as evidenced by the improvements in the model fit in comparison to models that only contain substantive factors. However, little is known regarding the capability of this model in recovering the uncontaminated person scores.

Bi-factor Exploratory Structural Equation Modeling Done Right: Using the SLiDapp Application.

Background: Due to its flexibility and statistical properties, bi-factor Exploratory Structural Equation Modeling (bi-factor ESEM) has become an often-recommended tool in psychometrics. Unfortunately, most recent methods for approximating these structures, such as the SLiD algorithm, are not available in the leading software for performing ESEM (i.e.

Entropy Fit Indices: New Fit Measures for Assessing the Structure and Dimensionality of Multiple Latent Variables.

The accurate identification of the content and number of latent factors underlying multivariate data is an important endeavor in many areas of Psychology and related fields. Recently, a new dimensionality assessment technique based on network psychometrics was proposed (Exploratory Graph Analysis, EGA), but a measure to check the fit of the dimensionality structure to the data estimated via EGA is still lacking. Although traditional factor-analytic fit measures are widespread, recent research has identified limitations for their effectiveness in categorical variables.

Investigating the performance of exploratory graph analysis and traditional techniques to identify the number of latent factors: A simulation and tutorial.

Exploratory graph analysis (EGA) is a new technique that was recently proposed within the framework of network psychometrics to estimate the number of factors underlying multivariate data. Unlike other methods, EGA produces a visual guide-network plot-that not only indicates the number of dimensions to retain, but also which items cluster together and their level of association. Although previous studies have found EGA to be superior to traditional methods, they are limited in the conditions considered.

Controlling for Response Biases in Self-Report Scales: Forced-Choice vs. Psychometric Modeling of Likert Items.

One important problem in the measurement of non-cognitive characteristics such as personality traits and attitudes is that it has traditionally been made through Likert scales, which are susceptible to response biases such as social desirability (SDR) and acquiescent (ACQ) responding. Given the variability of these response styles in the population, ignoring their possible effects on the scores may compromise the fairness and the validity of the assessments. Also, response-style-induced errors of measurement can affect the reliability estimates and overestimate convergent validity by correlating higher with other Likert-scale-based measures.

Assessing the Big Five with bifactor computerized adaptive testing.

Multidimensional computerized adaptive testing based on the bifactor model (MCAT-B) can provide efficient assessments of multifaceted constructs. In this study, MCAT-B was compared with a short fixed-length scale and computerized adaptive testing based on unidimensional (UCAT) and multidimensional (correlated-factors) models (MCAT) to measure the Big Five model of personality. The sample comprised 826 respondents who completed a pool with 360 personality items measuring the Big Five domains and facets.

Calibrating a new item pool to adaptively assess the Big Five.

Background: Even though the Five Factor Model (FFM) has been the dominant paradigm in personality research for the past two decades, very few studies have measured the FFM adaptively. Thus, the purpose of this research was the building of a new item pool to develop a computerized adaptive test (CAT) for personality assessment.

Method: A pool of 480 items that measured the FFM facets was developed and applied to 826 participants.

[Infectious bacteremic ecthyma in a patient with HIV infection].

Ecthyma is a deep ulcerative pyoderma usually caused by group A beta-hemolytic streptococcus (Streptococcus pyogenes). It usually presents in areas of damaged skin and in immunocompromised patients, and very infrequently is accompanied by general symptoms and bacteremia. We describe the case of a 41-year-old female patient with HIV infection who presented with fever and ulcerated lesions on the right ankle and left foot which had been developing for three weeks.

[Abnormal glycemic metabolism in essential hypertension. Role of the an oral glucose tolerance test].

Background And Objective: There is a high prevalence of diabetes in essential hypertensive patients, hence increasing the cardiovascular risk of these subjects. Our aim was to test the importance of a routine assessment of an oral glucose tolerance test (OGTT) in a sample of recently diagnosed essential hypertensives.

Patients And Method: We studied 270 recently diagnosed untreated hypertensives (56% males).