Publications by authors named "Maria D Corte-Torres"
PTEN-induced kinase-1 (PINK1) is the initiator of the canonical mitophagy pathway. Our aim was to study the immunoexpression of PINK1 in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver (CRLM). Tissue arrays were produced, and immunohistochemical studies were analyzed by the H-Score method.
View Article and Find Full Text PDFUnlabelled: Adult-type granulosa cell tumors (AGCT) are the most common type of malignant ovarian sex cord-stromal tumors. Most AGCTs carry the somatic variant c.402C>G (p.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma multiforme (GBM) is the most common and dangerous brain tumor in adults.
- The study finds that changes in DNA and a specific marker (H4K20me2) are linked to how GBM tumors behave and grow.
- Adding more of the H4K20me2 marker in tests showed it can act like a tumor suppressor and change how some cancer-related genes work.
Correlation of Micro-Computed Tomography Assessment of Valvular Mineralisation with Histopathological and Immunohistochemical Features of Calcific Aortic Valve Disease.
J Clin Med
December 2019
Aortic valve stenosis is a serious disease with increasing prevalence in developed countries. Research aimed at uncovering the molecular mechanisms behind its main cause, aortic valve calcification, is thus crucial for the development of future therapies. It is frequently difficult to measure the extent of mineralisation in soft tissues and some methods require the destruction of the sample.
View Article and Find Full Text PDFArticle Synopsis
- * In gliomas, DNA hypermethylation and decreased TET3 expression lead to a significant reduction in 5hmC levels, impacting overall gene regulation.
- * Increasing TET3 expression in glioblastoma cells enhances 5hmC levels, reduces cell growth, and improves prognosis, suggesting that TET3 repression contributes to tumor development.