Effect of diazepam on adenosine 3',5'-cyclic monophosphate (cAMP) plasma levels in anesthetized patients.

Background: It has been previously demonstrated that diazepam inhibits the cyclic nucleotide phosphodiesterase type 4 isozyme (PDE4). PDE enzymes mediate the hydrolysis of the nucleotide adenosine 3',5'-cyclic monophosphate (cAMP).

Objective: The aim of this study was to determine whether IV administration of diazepam affects cAMP plasma levels in anesthetized patients.

Amethocaine-lidocaine cream, a new topical formulation for preventing venopuncture-induced pain in children.

Background And Objectives: The aim of this study was to compare the effectiveness of 3 anesthetic creams in relieving venous puncture-related pain in children.

Methods: We performed a double-blind, randomized, prospective study in 300 patients, American Society of Anesthesiologists (ASA) I-II, aged 3 months to 10 years, scheduled for minor elective surgical procedures. These children were distributed into 3 groups, with 100 patients each, according to each type of cream applied to the back of the children's hands before performing the venous puncture: Group I was given EMLA (eutectic 2.