The effect of rosiglitazone on orthostatic tolerance during heat exposure in individuals with type II diabetes.

Background And Methods: Twenty-two subjects with type II diabetes and 30 control subjects participated in a 1-year study to examine the effect of rosiglitazone on heart rate variability at rest and the blood pressure, heart rate, and blood flow changes during a change in body position from horizontal to the 45 degrees head up position. To assess nerve damage, latency was measured for sensory nerves in the foot.

Results: The results of the experiments showed that subjects with diabetes had an approximate 50% impairment in sural, medial, and lateral plantar nerve latency.

The impact of rosiglitazone on heat tolerance in patients with type 2 diabetes.

Background: Diabetes is associated with reduced tolerance to heat. The insulin sensitizer rosiglitazone (RSG), administered for glycemic control, has a secondary effect in increasing vascular endothelial function. The hypothesis to be tested was if administration of rosiglitazone would increase heat tolerance in people with diabetes.