Publications by authors named "Maria Cristina Orlov-Slavu"
Article Synopsis
- - The study looked at the efficacy of the FOLFIRINOX chemotherapy regimen in patients with advanced pancreatic adenocarcinoma, analyzing data from 42 patients treated between 2017 and 2021.
- - Results showed a median progression-free survival (PFS) of 7.5 months and overall survival (OS) of 13.6 months, with those receiving more than six courses having better outcomes, but dose reduction and treatment delays also improved results significantly.
- - The findings suggest that while longer treatment is beneficial, administering full doses and maintaining dose intensity might not always be advantageous, and the overall toxicity rates were higher than previously reported.
Next-generation sequencing (NGS) is a fast and relatively inexpensive method to sequence a large number of genes with crucial importance in cancer medicine. Nowadays, NGS is frequently used in diagnostic and therapeutic decisions in oncology; however, recently, it was demonstrated that only a few cancer sites actually benefit from this assessment. Moreover, the association of a mutant gene with a targeted drug is not always as predicted during in-vitro trials and is often not associated with tumor response.
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