Publications by authors named "Maria Cristina Guarascio"
Assessment of treatment response in patients (pts) with leptomeningeal metastases (LM) represents a significant challenge and standardized criteria are needed. In 2017, the RANO LM Working Group proposed a standardized scorecard to evaluate MRI findings (further simplified in 2019). Here, we aim to validate the prognostic impact of response to treatment assessed using this tool in a multicentric cohort of breast cancer (BC) pts.
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- Brain metastases (BM) are prevalent in HER2+ breast cancer, and evaluating prognostic factors is essential for effective management.
- This study analyzed patients with HER2+ BCBM to determine the impact of extracranial disease control on overall survival (OS), finding a significant association in both exploratory and validation cohorts.
- The findings indicate that extracranial disease control offers unique prognostic insights that complement existing prognostic scores like BC-GPA, suggesting that it's crucial for patient outcomes.