Publications by authors named "Maria Cristina Gonzalez"

Body composition abnormalities are prognostic markers in several types of cancer, including colorectal cancer (CRC). Using our data distribution on body composition assessments and classifications could improve clinical evaluations and support population-specific opportune interventions. This study aimed to evaluate the distribution of body composition from computed tomography and assess the associations with overall survival among patients with CRC.

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  • - The study examines the rise of chronic conditions among older adults in Southern Brazil over six years, focusing on how demographic, socioeconomic, and behavioral health factors impact this trend.
  • - Researchers analyzed data from 1,098 participants aged 60 and older, finding that 30.9% had a low burden of conditions, 52.0% a moderate burden, and 17.1% a high burden, with various factors influencing risk levels.
  • - The findings suggest that a majority of older adults experience a moderate number of chronic conditions, and specific characteristics such as being male, older age, lack of education, and being a former smoker are linked to a higher burden of these conditions.
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Objectives: The study (PreopWeek) aimed to assess the perioperative nutritional care for major surgical patients in Brazilian hospitals, focusing on adherence to emerging multimodal protocols like Enhanced Recovery After Surgery and Acceleration of Total Postoperative Recovery.

Methods: An observational cross-sectional study was conducted in Brazilian hospitals enrolled voluntarily from June 19 to June 23, 2023 (convenience sample). Data were collected through patient interviews and medical records review.

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Background & Aims: Phase angle (PhA) is a biomarker derived from raw bioelectrical impedance analysis (BIA) values: resistance (R) and reactance (Xc). PhA reflects cellular membrane integrity and, as a result, has been considered a marker of fluid distribution, making it a potential prognostic indicator. A growing body of research demonstrates independent associations between PhA and muscle strength, mass, and composition.

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The 2-component molecular-level model dividing body mass into fat and fat-free mass (FFM) is a cornerstone of contemporary body composition research across multiple disciplines. Confusion prevails, however, as the term lean body mass (LBM) is frequently used interchangeably with FFM in scientific discourse. Are LBM and FFM the same or different body components? Captain Albert R.

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  • The study aimed to evaluate the accuracy of 40 predictive equations for estimating resting energy expenditure (REE) in women with breast cancer, comparing these predictions to measurements taken by indirect calorimetry.
  • The analysis included data from 90 participants (24% survivors, 61.1% early-stage cancer), revealing that none of the equations provided accurate REE estimates both at the group and individual levels, with significant biases observed.
  • These findings highlight the importance of using precise methods for calculating energy needs in women with breast cancer, as inaccuracies can impact treatment and recovery by influencing energy intake.
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  • Bioelectrical impedance analysis (BIA) is increasingly used for body composition estimation in both clinical and field settings, but device variations and equations can lead to inconsistent results.
  • This study evaluated raw resistance and reactance measurements from three different BIA devices to identify inter-device variation and its effect on body composition predictions among athletes.
  • Results showed significant differences in impedance measurements and body composition estimates across devices, with variations as large as 8.8 kg, underlining the importance of using population-specific equations for accurate assessments.
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Despite those with hepatocellular carcinoma (HCC) being at increased risk of malnutrition, there is a notable absence of practical approaches for nutritional assessment in clinical practice. We investigated the usefulness of phase angle (PhA) and Total Psoas Area Index (TPAI) for indicating nutritional risk and HCC prognosis. Weight, height, body mass index (BMI), adductor pollicis muscle thickness (APMT), and handgrip strength (HGS) were assessed.

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Objectives: Given the innovative nature of the method, our study aimed to assess the prognostic significance of body mass index (BMI)-adjusted calf circumference (CC) in older patients who are hospitalized.

Methods: This was a unique analysis as part of other cohorts comprising general hospitalized patients aged 60 years or older of both sexes. Only patients with excess weight (BMI ≥ 25 kg/m) were included.

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Background: This study aimed to evaluate if combining low muscle mass with additional body composition abnormalities, such as myosteatosis or adiposity, could improve survival prediction accuracy in a large cohort of gastrointestinal and genitourinary malignancies.

Methods: In total, 2015 patients with surgically-treated gastrointestinal or genitourinary cancer were retrospectively analyzed. Skeletal muscle index, skeletal muscle radiodensity, and visceral/subcutaneous adipose tissue index were determined.

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Background And Aims: Measurement of body composition using computed tomography (CT) scans may be a viable clinical tool for low muscle mass assessment in oncology. However, longitudinal assessments are often infeasible with CT. Clinically accessible body composition technologies can be used to track changes in fat-free mass (FFM) or muscle, though their accuracy may be impacted by cancer-related physiological changes.

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  • The study investigates the significance of muscle quality in cancer patients, focusing on a new metric called the strength-to-muscle-radiodensity index (SMRi) alongside the traditional muscle quality index (MQI).
  • Using CT scans and handgrip strength measurements from a cohort of 250 cancer patients, the researchers analyze the relationship between muscle strength, mass, and radiodensity.
  • Results indicate that both MQI and SMRi correlate strongly and that low values for these metrics are associated with shorter survival, with SMRi proving to be a more accurate predictor of mortality than MQI.
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To evaluate the association of standardized phase angle (SPA) with nutritional status, functional parameters, and postoperative outcomes in surgical cancer patients. This prospective study includes 59 cancer patients from Pelotas (Brazil) admitted for elective cancer surgery. We obtained the phase angle through Bioelectrical Impedance Analysis (BIA) and standardized it according to the population's reference values.

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Echo intensity determined by muscle ultrasound has been proposed as an efficient method for the assessment of muscle quality. The influence of changing ultrasound parameter settings on echo intensity values was assessed using a standardized approach. In this repeated measures cross-sectional study, sixteen repeated scans of rectus femoris, gracilis, and rectus abdominis were taken in 21 middle-aged persons with a portable Mindray M7 premium ultrasound machine equipped with a linear 5.

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  • - The longitudinal study in Brazil assessed how physical performance (PP) affects health outcomes like disability, falls, and hospitalization among older adults (N = 476, average age 68) over a 5-6 year period.
  • - Key tests used to measure PP were Gait Speed (GS) and Timed Up and Go (TUG), revealing that low performance in these areas correlated with increased disability, falls, and hospital stays after accounting for factors like economic status and health conditions.
  • - The findings suggest that regular assessments of physical performance can help identify older adults at risk for negative health outcomes, highlighting the importance of preventative measures.
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  • * In females, significant changes were observed in reactance to height (Xc/H) increasing, while resistance to height (R/H) decreased across all age groups; FFM also increased notably in younger age brackets.
  • * For males, both R/H and Xc/H showed decreases, and FFM increased throughout the ages studied, with phase angle (PhA) increasing in the oldest age group; the findings highlighted that changes in BI data differ between sexes.
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Background: Adiposity can influence the estimation of muscle mass using calf circumference (CC) and underestimate the frequency of low CC. An adjustment for CC using body mass index (BMI) was proposed to reduce this effect. We aimed to compare the low CC frequency in hospitalized patients when considering raw and BMI-adjusted values and explore data by sex, age, and race (white and non-white).

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  • - The study explored the use of Direct Oral Drug Provocation Test (DODPT) to safely assess beta-lactam antibiotic (BLA) allergies in children, revealing that over 90% of suspected cases could be ruled out effectively.
  • - It involved 2,133 young patients across 15 hospitals in Spain, noting that most had mild reactions; only a handful experienced severe reactions, such as anaphylaxis, which resolved quickly with treatment.
  • - The results suggest that DODPT is a reliable method for confirming or denying BLA allergies, making it a practical option for doctors in pediatric care to help "delabel" unnecessary allergies.
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Background: Loss of muscle mass (MM) in hospitalized patients has been associated with negative outcomes, thus, evaluating this biomarker is important to stratify risk. Although studies have been showing that calf circumference (CC) and bioelectrical impedance analysis (BIA) are valid for estimating MM in hospitalized patients, we do not know if they are associated. The aim of this study was to evaluate the associations between CC and BIA in hospitalized patients.

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Objectives: To assess the concurrent and predictive validity of different combinations of Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with colorectal cancer considering different indicators of reduced muscle mass (MM) and the effects of the disease.

Methods: A secondary analysis with patients with colorectal cancer. The reduced MM was assessed by arm muscle area, arm muscle circumference, calf circumference, fat-free mass index, skeletal muscle index (SMI) and skeletal muscle.

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Aims: This scoping review aimed to identify, explore, and map the objectives, methodological aspects, and results of studies that used ultrasound (US) to assess skeletal muscle (SM) in critically ill patients.

Methods: A scoping review was conducted according to the Joanna Briggs Institute's methodology. All studies that evaluated SM parameters from the US in patients admitted to the intensive care unit (ICU) were considered eligible.

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Background: Despite advancements in the global dialog surrounding sex and gender equity, an important gap persists with women markedly underrepresented in major roles within health care leadership.

Objectives: We examined the extent of women's representation in prominent positions within parenteral and enteral nutrition (PEN) societies worldwide over a span of 2 decades.

Design: This retrospective analysis explored the sex distribution of society chairs, conference presidents, and editor-in-chief positions across 64 PEN societies between 2003 and 2022.

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