Publications by authors named "Maria Cristina Ferreira de Sousa"

Article Synopsis
  • Toxoplasma gondii and Neospora caninum are significant pathogens causing health issues globally, and Bumped Kinase Inhibitors (BKIs) represent a promising class of drugs targeted at combating these infections.
  • BKI-1708, a specific BKI, has shown strong in vitro potency against these pathogens while maintaining high safety for human cells, indicated by its minimal effect on human foreskin fibroblast viability.
  • In animal studies, BKI-1708 demonstrated an ability to reduce parasite loads in pregnant mice without affecting their pregnancy outcomes, highlighting its potential as a treatment for these infections.
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Neospora caninum is an apicomplexan and obligatory intracellular parasite, which is the leading cause of reproductive failure in cattle and affects other farm and domestic animals, but also induces neuromuscular disease in dogs of all ages. In cattle, neosporosis is an important health problem, and has a considerable economic impact. To date there is no protective vaccine or chemotherapeutic treatment on the market.

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Organometallic compounds, including Ruthenium complexes, have been widely developed as anti-cancer chemotherapeutics, but have also attracted much interest as potential anti-parasitic drugs. Recently hybrid drugs composed of organometallic Ruthenium moieties that were complexed to different antimicrobial agents were synthesized. One of these compounds, a trithiolato-diRuthenium complex (RU) conjugated to sulfadoxine (SDX), inhibited proliferation of Toxoplasma gondii tachyzoites grown in human foreskin fibroblast (HFF) monolayers with an IC < 150 nM, while SDX and the non-modified RU complex applied either individually or as an equimolar mixture were much less potent.

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