Publications by authors named "Maria Cristina Bue"
MicroRNAs are a class of sophisticated regulators of gene expression, acting as post-transcriptional inhibitors that recognize their target mRNAs through base pairing with short regions along the 3'UTRs. Several microRNAs are tissue specific, suggesting a specialized role in tissue differentiation or maintenance, and quite a few are critically involved in tumorigenesis. We studied miR-128, a brain-enriched microRNA, in retinoic acid-differentiated neuroblastoma cells, and we found that this microRNA is up-regulated in treated cells, where it down-modulates the expression of two proteins involved in the migratory potential of neural cells: Reelin and DCX.
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- Angiogenesis is crucial for the growth and spread of glioblastoma multiforme (GBM), with VEGF being a key driver of increased blood vessel formation.
- A study utilized VEGF siRNA delivered through a plasmid to reduce blood vessel growth in xenograft tumors, but it did not decrease tumor size.
- By combining VEGF siRNA with an antiangiogenic agent (mIL4), researchers found that this dual treatment completely halted tumor growth, indicating its potential for use in future gene therapy for GBM.