Modulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols.

Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium () cation. Among these compounds, a number of molecular detectors for reactive oxygen species (ROS) are based on fluorescent and chemiluminescent probes.

Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: copper(II).

The presence of copper(II) in the micromolar range modulates the photodegradation rate of the fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. The photodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and no change in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rate increases with increasing copper(II) concentration and the photoproducts distribution changes.