Insulin resistance predicts steatosis and fibrosis in morbidly obese patients undergoing bariatric surgery.

Background: Influence of adipokines and insulin resistance on liver histology is an unclear area in morbidly obese patients.

Objective: The aim of our study was to study the influence of insulin resistance and adipokines in the grade of liver steatosis and fibrosis in morbidly obese patients undergoing bariatric surgery.

Setting: Tertiary hospital.

Relation of osteocalcin with insulin resistance and histopathological changes of non alcoholic fatty liver disease.

Background: Osteocalcin is a hormone with a complex cross-talk between adipose tissue and the skeleton. The aim of the present study was to explore the relation of osteocalcin with histopathological changes of NALFD patients.

Subjects: A population of 69 NAFLD patients was analyzed.

G308A polymorphism of TNF-alpha gene is associated with insulin resistance and histological changes in non alcoholic fatty liver disease patients.

Some studies have pointed to a role of TNF-alpha in pathogenesis of non alcoholic fatty liver disease (NAFLD). The aim of our study was to investigate the influence of G308A polymorphism TNF alpha gene on the histological changes, insulin resistance and TNF-alpha levels in overweight patients. A population of 66 patients with NAFLD was recruited in a cross sectional study.