Publications by authors named "Maria Clara Ortiz"
Article Synopsis
- Maternal diabetes during pregnancy leads to sex-specific differences in cardiovascular and renal health in offspring, with male offspring showing worse outcomes than female offspring.
- The study found that male offspring had higher blood pressure, increased renal resistance, and worse blood vessel responses compared to their female counterparts from diabetic mothers, suggesting a protective mechanism in females.
- This protection in female offspring is linked to higher levels of heme oxygenase-1 (HO-1) and lower oxidative stress, indicating that HO activity might help mitigate the adverse effects of maternal diabetes on cardiovascular and renal function.
Many studies have shown that flavonoids are effective as antihypertensive drugs in arterial hypertension. In the present work, we have analyzed the effects of some flavonoid extracts in the spontaneous hypertensive rat model (SHR). An important feature of this study is that we have used a low dose, far from those that are usually applied in human therapy or experimental animals, a dose that responded to the criterion of a potential future commercial use in human subjects.
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