Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism.

The association between genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS.