[Drug-induced hypersensitivity syndrome--a literature review and the case report].

Drug-induced hypersensitivity syndrome (DIHS) is characterized by fever, rash and internal organ involvement, mostly in form of hepatitis, myocarditis, nephritis or pneumonitis, which may occur 1-8 weeks after medicine exposure. Fever is an early feature, usually preceding a widespread erythematous skin eruption, but the severity of the skin-related changes does not correlate with the extent of internal organ involvement. It is considered that anticonvulsants (particularly carbamazepine), antibiotics, allopurinol are the most frequent causative agents of DIHS.

A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis.

Recently we described an association between psoriasis and KIR2DS1, a gene for a stimulatory natural killer cell receptor, in a Polish population. The association was independently reported among Japanese and confirmed in a U.S.

Psoriasiform lupus vulgaris with 30 years duration.

Lupus vulgaris is a progressive form of cutaneous tuberculosis occurring in a person with a moderate to high degree of immunity. It is the most common type of cutaneous tuberculosis. Lupus vulgaris can be mimicked by several other skin conditions, and a 69-y-old female is described with an extremely long history of extensive infiltrative skin lesions with abundant scaling.

[Darier disease type 1].

Darier disease (follicular dyskeratosis) is a rare genodermatosis determined by an autosomal dominant gene with variable penetration, characterized by a symmetrical eruption of hyperkeratotic papules with predilection to the seborrheic areas of the body. Unilateral, focal form is the one of the rare type of the Darier disease. Two clinical and genetical phenotypes of the segmental Darier disease have been recently reported: type 1--in which the skin outside of the localized manifestation is normal and type 2--showing a segmental affection in combination with diffuse skin involvement.

Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.

Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw*06 allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence of particular KIR genes.

Familial cutaneous and uterine leiomyomas: case report.

Cutaneous leiomyomas are rare, benign tumors arising from the arrectores pilorum muscles of the skin, the tunica dartos of the scrotum, muscles of the areola of the nipple, and vulvar or vascular smooth muscles. Multiple cutaneous leiomyomas originate from the arrectores pilorum muscles of the skin (piloleiomyomata cutis). Occasionally, they seem hereditary and may be associated with uterine myomas.

Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls.

The leukocyte immunoglobulinlike receptor (LILRA3; ILT6) gene is localized on human chromosome 19 in the region 19q13.4, in the leukocyte receptor complex that encodes leukocyte receptors LILR (ILT/LIR), killer cell immunoglobulinlike receptors (KIR), LAIR, Fc IgA receptor, and others. The biologic role of the LILRA3 molecule and the nature of its ligand are not known.

Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients.

Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls.

[Skin changes during the course of selected endocrinologic diseases in children and adolescents].

The authors presented skin lesions which may be observed in selected endocrinopathies in children and adolescents. Functional disturbances of endocrine glands in which skin lesions may develop are dysfunction of the adrenals, gonads in case of children, thyroid diseases and diabetes type 1. The authors presented also a detailed description of skin symptoms observed in hyperthyrosis and hypothyrosis.

Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris.

Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B. However, HLA-linked complement component polymorphic genes were not extensively studied.