Publications by authors named "Maria Cichalewska"
Article Synopsis
- This study explores how exosomes, tiny vesicles that carry RNA, may play a role in the immune regulation of relapsing-remitting multiple sclerosis (RRMS) compared to healthy controls (HC).
- Researchers used next generation sequencing (NGS) to analyze the exosomal RNA profiles in 19 RRMS patients and 10 HC, identifying specific microRNAs (miRNAs) that were differentially expressed and significantly decreased during RRMS relapses.
- The findings suggest that the unique RNA profile in exosomes of RRMS patients could indicate disrupted communication between cells and that certain miRNAs might serve as potential biomarkers to differentiate between disease relapses.
Unlabelled: microRNA-155 (miR-155) plays an important role in posttranscriptional gene regulation of the immune system. We and others have described miR-155 upregulation in T helper cells (Th) during the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We have shown that mice in which the miR-155 host gene (MIR155HG) has been deactivated are resistant to EAE.
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- MicroRNAs (miRNAs) play a key role in forming RNA-induced silencing complexes (RISCs) which regulate miRNA activity; however, their function in diseases like multiple sclerosis (MS) and its model, experimental autoimmune encephalomyelitis (EAE), remains unclear.
- Recent findings show that the levels of RISC proteins, specifically Ago2 and FXR1, are significantly dysregulated in various cell types during EAE, impacting oligodendrocytes and brain-infiltrating T cells.
- The altered RISC assembly leads to downregulation of miRNAs necessary for oligodendrocyte survival and myelin production, while promoting proinflammatory responses in T lymphocytes, suggesting a possible link
Article Synopsis
- * In this study, researchers found that sulfatides significantly suppress T cell proliferation, especially in naive T helper cells, and this suppression is not related to cell death but rather to the induction of a state called anergy.
- * The study highlights sulfatides as key players in regulating T cell functions negatively and suggests their involvement in reducing susceptibility to autoimmune diseases, like multiple sclerosis, which shifts the focus from just myelin proteins to other brain-derived molecules.
Plasmacytoid dendritic cells (pDCs), an important immunoregulatory population, are characterized by vigorous secretion of type I interferons (IFNs) in response to toll-like receptor (TLR) 7 and 9 stimulation. We studied the function of pDCs in multiple sclerosis (MS) patients by analysis of TLR7 responses. We assessed a pDC secretion pattern of cytokines in the short term PBMC cultures stimulated with TLR7 agonist.
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- * This study found that specific miRNAs (miR-301a, miR-21, and miR-155) were significantly upregulated in CD4(+) T cells upon stimulation with myelin autoantigen, MOG(35-55), and were overexpressed in T cells in the central nervous system of animals with autoimmune encephalomyelitis.
- * miR-301a was shown to promote T-helper type 17 cell development by targeting the IL-6/23-STAT3 pathway, and manipulating miR-301