Publications by authors named "Maria Chiara Sala"
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior.
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- The study aimed to create fast dissolving films for delivering quercetin nanocrystals, using maltodextrins as the main material and glycerin for flexibility, to improve quercetin's oral absorption.
- Quercetin nanosuspensions were made using a high-pressure homogenizer and then used to make the films through a casting method; analysis showed that reducing quercetin to nanoscale didn't alter its solid form within the films.
- The presence of quercetin nanocrystals in the films changed their properties, making them more elastic and ductile, while the dissolution rate of both the free and film-embedded quercetin was significantly higher compared to regular quercetin.
Recently, we carried out a research on new liposomal systems prepared by using in their composition a few penetration enhancers which differ for chemical structure and physicochemical properties. The penetration enhancer-containing vesicles (PEVs) were prepared by using soy lecithin and different amounts of three penetration enhancers, 2-(2-ethoxyethoxy) ethanol (Transcutol(®)), capryl-caproyl macrogol 8-glyceride (Labrasol(®)), and cineole.To study the influence of the PEVs on (trans)dermal delivery of minoxidil, in vitro diffusion experiments were performed through new born pig skin and the results were compared with that obtained applying the vesicular system without enhancer (control) after pretreatment of the skin with the various enhancers.
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