Publications by authors named "Maria Chiara Meloni"
Article Synopsis
- Cryptic species are fungi that can cause human diseases and are resilient in diverse environments, often developing resistance to antifungal treatments used in agriculture.
- Advances in molecular techniques have improved the identification of these pathogens, but their full significance in clinical settings remains understudied.
- A multidisciplinary approach, known as the One Health initiative, is essential for understanding and managing these fungi, as their impact spans human, animal, and environmental health, highlighting the need for enhanced awareness and research in this area.
Article Synopsis
- A new prognostic model for COVID-19 progression was developed to include vaccination status and early treatment, which were missing from previous scores.
- The study analyzed data from 1,145 patients in Sassari, revealing that older age, comorbidities, and lack of vaccination were linked to disease progression, where 29.3% of patients required supplemental oxygen.
- Multivariate analysis identified key risk factors for progression and created an easy-to-use scoring system based on various clinical and demographic variables, enhancing the ability to predict patient outcomes.
Since the start of the SARS-CoV-2 pandemic, several treatments have been proposed to prevent the progression of the disease. Currently, three antiviral (molnupiravir, nirmaltrevir/r, remdesivir) and two monoclonal antibodies (casirivimab/imdevimab and sotrovimab) are available in Italy. Therefore, we aimed to evaluate the presence of risk factors associated with disease progression.
View Article and Find Full Text PDFSince the start of the SARS-CoV-2 pandemic, several scores have been proposed to identify infected individuals at a higher risk of progression and death. The most famous is the 4C score. However, it was developed in early 2020.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of remdesivir, the first antiviral approved for COVID-19, in reducing mortality among patients infected with SARS-CoV-2.
- Researchers conducted a case-control study using medical records from patients in two hospitals in Italy, focusing on those admitted between July 2020 and November 2021.
- Results showed that patients receiving remdesivir had significantly lower mortality rates, indicating its potential as an effective treatment for COVID-19, especially when combined with heparin.
Since the start of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several treatments have been proposed to cure coronavirus disease 2019 (COVID-19) and prevent it. Molnupiravir is a ribonucleoside prodrug of N-hydroxycytidine with an in vitro and in vivo activity against SARS-CoV-2. We conducted a retrospective cohort study that included all people treated with molnupiravir between January 10, 2022, and March 31, 2022, at the University Hospital of Sassari.
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- Prevention campaigns have successfully reduced new HIV diagnoses in Western Europe, but awareness of other STIs among the general population, particularly in Italy, remains low, especially among individuals over 50 years old.
- A questionnaire distributed to 2183 people revealed that many lacked knowledge about safe practices and the Undetectable = Untransmittable (U = U) initiative, with 97.6% agreeing that more educational campaigns are necessary.
- The study emphasized the need for tailored educational efforts, indicating that surveys can be effective tools for raising awareness and improving knowledge about HIV and STIs across different demographic groups.
Purpose: vascularized fibular grafting has been used to treat osteonecrosis of the femoral head in younger patients. Although the results described in the literature are promising, the failure rate is still significant, especially in steroid users. This study was undertaken to learn more, on a histopathological level, about the mechanism of vascularized fibular graft failure.
View Article and Find Full Text PDFA good outcome in total knee arthroplasty depends on many factors: joint alignment, range of motion, patellar tracking and ligament stability. A correct soft tissue balance keeps the joint aligned in flexion and extension, and therefore constitutes the most important factor for durability of the implant. Indeed, incorrect soft tissue balancing is the primary cause of early implant failure necessitating revision surgery.
View Article and Find Full Text PDFResults of arthroscopic management of chronic, recalcitrant calcific tendinopathy of the shoulder in 28 patients were evaluated. Twenty-six patients (average age, 44 years) were ultimately enrolled in the study. Postoperative radiographs were performed to determine the amount of calcium deposit removal.
View Article and Find Full Text PDFSelective electrophysiological involvement of median motor fibers is rare in carpal tunnel syndrome. We report a patient with compression neuropathy of the median nerve who presented with isolated motor signs and symptoms without macroscopic evidence of compressive pathologies.
View Article and Find Full Text PDFWe report a case of para-articular chondroma located in the infrapatellar fat pad of the knee of a 42-year-old woman with a history of anterior knee pain and restricted range of motion. On clinical examination, a solid palpable mass in the infrapatellar region was detected. Radiography and computed tomography of the knee revealed the presence of 3 different "popcorn"-like gross calcifications within Hoffa's fat pad.
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