Publications by authors named "Maria Chiara Longo"
Lymphoproliferative diseases arise when the physiological mechanisms that control the proliferation of T and B lymphocytes are disrupted, resulting in an uncontrolled and autonomous increase in immune cells leading to lymphocytosis and lymphadenopathy, and often to the involvement of extranodal sites. The differential diagnosis of malignant T cell tumors involves other neoplasms and non-clonal T cell proliferations. Immunological markers are essential, as a first step, to distinguish between T-cell and non-T-cell disorders.
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- Inflammatory bowel diseases (IBDs) increase the risk of hematological malignancies (HMs), and clonal hematopoiesis (CH)—a condition marked by acquired mutations—has been found more frequently in IBD patients.
- A study analyzed thirteen IBD patients with HMs and found that 85% had mutations in genes linked to CH, suggesting inflammation could promote the growth of these harmful cell clones.
- If these findings are confirmed, IBD patients with CH mutations may need further monitoring for HMs to understand the potential connections between these health issues.